Non small cell lung cancer classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]

Classification

• The most common type of lung cancer is non–small cell lung cancer (NSCLC). About 85%–90% of all lung cancers are non–small cell lung cancer. The other 10%–15% are small cell lung cancer.

• There are 3 main types of non–small cell lung cancer: adenocarcinoma, squamous cell carcinoma and large cell carcinoma.

Subtypes

• Adenocarcinoma

• Adenocarcinoma, mixed subtype

• Acinar adenocarcinoma

• Papillary adenocarcinoma

• Bronchioloalveolar carcinoma

• Nonmucinous

• Mucinous

• Mixed nonmucinous and mucinous or indeterminate

• Solid adenocarcinoma with mucin production

• Fetal adenocarcinoma

• Mucinous (“colloid”) carcinoma

• Mucinous cystadenocarcinoma

• Signet ring adenocarcinoma

• Clear cell adenocarcinoma

• Squamous cell carcinoma

• Papillary

• Clear cell

• Small cell

• Basaloid

• Large cell carcinoma

• Large cell neuroendocrine carcinoma

• Basaloid carcinoma

• Lymphoepithelioma-like carcinoma

• Clear cell carcinoma

• Large cell carcinoma with rhabdoid phenotype

• Adenosquamous carcinoma

• Sarcomatoid carcinoma

• Pleomorphic carcinoma

• Spindle cell carcinoma

• Giant cell carcinoma

• Carcinosarcoma

• Pulmonary blastoma

• Carcinoid tumor

• Typical carcinoid

• Atypical carcinoid

• Salivary gland tumor

• Mucoepidermoid carcinoma

• Adenoid cystic carcinoma

• Epithelial-myoepithelial carcinoma

References

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