Langerhans cell histiocytosis pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]

Microscopic Pathology

On microscopic histopathological analysis, findings of langerhans cell histiocytosis include:

• Langerhans cells histiocytes

• Clusters of cells (histiocytes) with a reniform (kidney-shaped) nucleus and abundant foamy cytoplasm.

• Nucleus may look like a "coffee bean", that is have nuclear grooves, appearance dependent on the rotation of the nucleus.
• May be called "buttock cells".

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