Langerhans cell histiocytosis pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]

Overview

On microscopic histopathological analysis, findings of langerhans cell histiocytosis include:^[1]

Clusters of cells (histiocytes) with a reniform (kidney-shaped) nucleus and abundant foamy cytoplasm.

Nucleus may look like a "coffee bean", that is have nuclear grooves, appearance dependent on the rotation of the nucleus.
May be called "buttock cells".

Langerhans cell histiocytosis is demonstrated by positivity to:^[2]

On electron microscopy, findings of langerhans cell histiocytosis include:^[3]

↑ Microscopic features of langerhans cell histiocytosis. Librepathology (2015). http://librepathology.org/wiki/index.php/Langerhans_cell_histiocytosis. December 21, 2015
↑ Immunohistochemistry of langerhans cell histiocytosis. Librepathology (2015). http://librepathology.org/wiki/index.php/Langerhans_cell_histiocytosis. December 21, 2015
↑ Electron microscopy of langerhans cell histiocytosis. Librepathology (2015). http://librepathology.org/wiki/index.php/Langerhans_cell_histiocytosis. December 21, 2015