Serratia infection medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Medical Therapy
Antimicrobial regimen
- Serratia marcescens[1]
- 1. Bacteremia, pneumonia or serious infections
- Preferred regimen (1): Cefepime 1-2 g IV q8h
- Preferred regimen (2): Imipenem 0.5-1.0 g IV q6h
- Preferred regimen (3): Ciprofloxacin 400 mg IV q8h
- Alternative regimen (1): Aztreonam
- Alternative regimen (2): Gentamicin
- Alternative regimen (3): Amikacin
- Alternative regimen (4): Piperacillin-tazobactam also often effective
- Note: Duration depends on clinical response, usually 7-14 days
- 2. Endocarditis
- Note: Choice dictated by sensitivities, 4 to 6 week duration of parenteral therapy.
- 3. Osteomyelitis
- Note (1): Choice dictated by sensitivity profile, treat for 6-12 weeks depending upon response.
- Note (2): Use IV treatment until stable/clinically improved (10-14 days Minimum) then may convert to oral therapy if appropriate.
- 4. UTI
- Preferred regimen (1): Ciprofloxacin 250 mg PO bid or 400 mg IV q12h
- Preferred regimen (2): Levofloxacin 250 mg PO qd or 500mg IV q24h
- Note: Fluoroquinolones often sensitive but in seriously ill patient consider empiric coverage with two drugs (e.g.,beta-lactam and aminoglycoside or fluoroquinolones and carbapenem) until susceptibilities known.
References
- ↑ Bartlett, John (2012). Johns Hopkins ABX guide : diagnosis and treatment of infectious diseases. Burlington, MA: Jones and Bartlett Learning. ISBN 978-1449625580.