Sporotrichosis medical therapy

Sporotrichosis Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Sporotrichosis from other Diseases
Epidemiology and Demographics
Risk Factors
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
Chest X Ray
Treatment
Medical Therapy
Surgery
Prevention
Case Studies
Case #1
Sporotrichosis medical therapy On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Sporotrichosis medical therapy All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Sporotrichosis medical therapy
CDC on Sporotrichosis medical therapy
Sporotrichosis medical therapy in the news
Blogs on Sporotrichosis medical therapy
Directions to Hospitals Treating Sporotrichosis
Risk calculators and risk factors for Sporotrichosis medical therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alison Leibowitz [2]

Treatment

Form	Primary Line of Treatment	Alternative Treatment	Remarks/Other
Uncomplicated cutaneous	Itraconazole [200 mg/day]	Itraconazole [200 mg PO bid], terbinafine [500 mg PO bid], SSKI [increasing doses], fluconazole [400-800 mg/day], OR local hyperthermia	Continue treatment for 2-4 weeks after lesions resolve.
Osteoarticular	Itraconazole [200 mg PO bid]	Limposomal amphotericin B [3-5 mg/kg/day] OR deoxycholate amphotericin B [0.7-1 mg/kg/day] until symptom resolution	For a total of 12 months, switch to itraconazole after resolution/end of treatment.
Pulmonary	Limposomal amphotericin B [3-5 mg/kg/day], THEN followed by itraconazole [200 mg PO bid]	Deoxycholate amphotericin B [0.7-1 mg/kg/day], THEN followed by itraconazole [200 mg PO bid] upon symptom resolution	Treat less sever cases with a 12 month regimen of itraconazole.
Meningeal	Limposomal amphotericin B [3-5 mg/kg/day], THEN followed by itraconazole [200 mg PO bid]	Deoxycholate amphotericin B [0.7-1 mg/kg/day], THEN followed by itraconazole [200 mg PO bid] upon symptom resolution	Precise length of amphotericin B treatment varies. Suppressive treatment with itraconazole is necessary.
Dissimated	Limposomal amphotericin B [3-5 mg/kg/day], THEN followed by itraconazole [200 mg PO bid.]	Deoxycholate amphotericin B [0.7-1 mg/kg/day], THEN followed by itraconazole [200 mg PO bid] upon symptom resolution	Continue amphotericin B treatment until patient shows marked improvement for a minimum of 12 months. Suppressive treatment with itraconazole is necessary.
Sporotrichosis in pregnant women	Treat with limposomal amphotericin B [3-5 mg/kg/day] OR deoxycholate amphotericin B [0.7-1 mg/kg/day] only for severe cases of sporotrichosis. In cases of uncomplicated cutaneous, treat with only hyperthermia.		It is preferable to defer treatment in uncomplicated cases.
Sporotrichosis in Children	Itraconazole [6-10 mg/day to a max of 400 mg] for mild cases Deoxycholate amphotericin B [0.7-1 mg/kg/day] for severe cases	SSKI [increasing doses equivalent to half the adult dose], continuing treatment for 2-4 weeks after resolution of symptoms.