Splenic marginal zone lymphoma natural history, complications and prognosis
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Splenic marginal zone lymphoma Microchapters |
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Differentiating Splenic marginal zone lymphoma from other Diseases |
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Diagnosis |
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Treatment |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Prognosis
Three-quarters of patients survive five or more years; more than half of patients with SMZL survive more than a decade after diagnosis.[1]
Patients who have a hemoglobin level of less than 12 g/dL, a lactate dehydrogenase level higher than normal, and/or a blood serum albumin levels of less than 3.5 g/dL are likely to have more an aggressive disease course and a shorter survival.[1] However, even high-risk patients have even odds of living for five years after diagnosis.[1]
Some genetic mutations, such as mutations in NOTCH2, are also correlated with shorter survival.