Paracoccidioidomycosis pathophysiology

Paracoccidioidomycosis Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Danitza Lukac

Pathogenesis

• Spores of paracoccidioides are transmitted via the respiratory route to the human host
• Conidia and mycelial particles "reach the terminal brochioles and alveoli, where they are transformed into yeast cell"
• "the infection can spread to other tissues via lymphatic and hematic"

• "The fungi developed mechanisms (such as adhesion to host cells), to avoid entrapment within mucus and their elimination by mucigen cilliary cells"
• "their effective adherence contributes to higher speed invasion of host cells, allowing for evasion of the immune system"