Splenic marginal zone lymphoma natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Three-quarters of patients survive five or more years; more than half of patients with SMZL survive more than a decade after diagnosis.^[1]

Aggressive disease course and a shorter survival. However, even high-risk patients have even odds of living for five years after diagnosis.^[1]

Patients who have a Template:Hemoglobin level of less than 12 g/dL
Lactate dehydrogenase level higher than normal
Blood serum albumin levels of less than 3.5 g/dL
Some genetic mutations, such as mutations in NOTCH2, are also correlated with shorter survival

↑ ^1.0 ^1.1 Arcaini, L. (2006). "Splenic marginal zone lymphoma: a prognostic model for clinical use". Blood. 107 (12): 4643–4649. doi:10.1182/blood-2005-11-4659. ISSN 0006-4971.