Splenic marginal zone lymphoma natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Low Hemoglobin levels, high lactate dehydrogenase levels, low blood serum albumin levels, and genetic mutations such as mutations in NOTCH2 are associated with poor prognosis among patients with splenic marginal zone lymphoma.
Prognosis
- Poor prognosis criteria for splenic marginal zone lymphoma include: [1]
- Hemoglobin level of less than 12 g/dL
- Lactate dehydrogenase level higher than normal
- Blood serum albumin levels of less than 3.5 g/dL
- Some genetic mutations, such as mutations in NOTCH2, are also correlated with shorter survival
References
- ↑ Arcaini, L. (2006). "Splenic marginal zone lymphoma: a prognostic model for clinical use". Blood. 107 (12): 4643–4649. doi:10.1182/blood-2005-11-4659. ISSN 0006-4971.