Pertussis other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Serge Korjian M.D.; Aditya Govindavarjhulla, M.B.B.S. [2]; Luke Rusowicz-Orazem, B.S.; Yazan Daaboul, M.D.

Overview

Pertussis can also be diagnosed using direct flourescent antibody (DFA) and pulsed-field gel eletrophoresis tests.

Direct fluorescent antibody (DFA)
- DFA is inexpensive and may provide rapid results.^[1]
- It's drawbacks, however, include poor sensitivity and specificity.^[1]
Pulsed-field gel electrophoresis (PFGE)
- PFGE is a DNA fingerprinting technique that has the following advantages:^[2]
  - Highly discriminating in its results^[3]
  - Easily applicable to Bordetella pertussis^[3]
  - Stable and easily reproduced^[3]
- PFGE's drawbacks include duration of time to perform as well as required a specifically trained and skilled technician.^[3]

↑ ^1.0 ^1.1 Miagkaia IP (1978). "[Antireticular cytotoxic serum as an agent for stimulating the immunity system]". Zh. Mikrobiol. Epidemiol. Immunobiol. (in Russian) (12): 82–6. PMID 85400.
↑ Brown DD, Juhl RP, Warner SL (1979). "Effects of hypocholesterolemic interventions on digoxin bioavailability". Drug Metab. Rev. 9 (1): 107–17. PMID 446263.
↑ ^3.0 ^3.1 ^3.2 ^3.3 "Pulsed-field Gel Electrophoresis (PFGE) | Pathogens and Protocols | PulseNet | CDC".