Neoplastic meningitis laboratory tests
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Laboratory Findings
Laboratory findings consistent with the diagnosis of neoplastic meningitis include:[1]
CSF analysis
- Neoplastic meningitis is multifocal and cerebrospinal fluid at a particular site may show no abnormalities, if the pathological site is far away. Only 50% of those suspected with neoplastic meningitis are actually diagnosed and only the presence of malignant cells in the CSF is diagnostic.[1]
- The criteria for CSF abnormalities that are consistent with the diagnosis of neoplastic meningitis include:[1]
- Increased opening pressure (> 200mm of H2O)
- Increased Leukocytes (>4/mm3)
- Elevated protein (>50 mg/dL)
- Decreased glucose (<60 mg/dL)
- Positive tumor markers in CSF
- Carcinoembryonic antigen (CEA)
- Alpha-fetoprotein
- Beta-human chorionic gonadotropin
- Creatine-kinase BB isoenzyme
- Beta-2 microglobulin
- Lactate dehydrogenase isoenzyme-5
- Vascular endothelial growth factor
- These markers can be good indirect indicators of n eoplastic meningitis, but most are not sensitive enough to improve cytological diagnosis.
References
- ↑ 1.0 1.1 1.2 Diagnosis of neoplastic meningitis. Wikipedia 2016. https://en.wikipedia.org/wiki/Neoplastic_meningitis. Accessed on January 20, 2016