Osteochondroma overview
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]
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Overview
Osteochondroma (also known as osteocartilaginous exostosis) is a benign bone tumor that consists of cartilage and bone. Osteochondromas arise from cartilage, which is normally involved in the mechanical support of the bone. These tumors take the form of cartilage-capped bony projections or outgrowth on the surface of bones, also known as exostoses.[1] Osteochondroma is the most common benign bone tumor and usually occurs in the metaphyseal region of the long bones. Development of osteochondromas is the result of the developmental anomaly of skeletal growth.The majority of these tumors present as solitary, non hereditary lesions. Osteochondromas are usually found in adolescents and children. Men and women are equally affected. The incidence of osteochondroma is approximately 0.9 per 100,000 individuals. If left untreated, progression occurs slow and is then followed by malignant transformation. The treatment choice for osteochondroma is surgical removal of solitary lesion or partial excision of the outgrowth, when symptoms cause motion limitations or nerve and blood vessel impingements.
Historical Perspective
Osteochondroma was first described by Henry L. Jaffe in 1952.[2]
Classification
Pathophysiology
Osteochondroma arises from the cartilage cells, which are normally involved in the mechanical support of the bone. Osteochondroma is a slow and benign growing tumor which may transform malignant after time. Genes involved in the pathogenesis of osteochondroma include germ line mutations in EXT1 and EXT2 genes. Osteochondroma is associated with a number of syndromes that include. On gross pathology, On microscopic histopathological analysis,
Causes
There are no established direct causes for osteochondroma. The development of hereditary multiple osteochondroma may be the result of multiple genetic mutations.
Differentiating Osteoid Osteoma from other Diseases
Osteochondroma must be differentiated from other diseases that cause a growth after skeletal maturity, a palpable lump, and a malunited fracture such as enchondroma, chondroblastoma, and intraosseous ganglion.
Epidemiology and Demographics
Osteochondroma is the most common benign bone tumor among general population. The incidence of osteochondroma is approximately 0.9 per 100,000 individuals in the general population. The incidence of osteochondroma decreases with age; the median age at diagnosis is between 10 to 13 years. Males and females are equally affected with osteochondroma. Osteochondroma usually affects individuals of the Caucasian race.
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Staging
History and Symptoms
Physical Examination
Laboratory Findings
X Ray
CT
MRI
Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Surgery is the mainstay of therapy for osteochondroma.
Primary Prevention
Secondary Prevention
References
- ↑ Panagiotis, Kitsoulis; Vassiliki Galani; Kalliopi Stefanaki; Georgios Paraskevas; Georgios Karatzias; Niki John Agnantis; Maria Bai (October 2008). "Osteochondromas: Review of the Clinical, Radiological and Pathological Features". In Vivo. 22 (5): 633–646. Retrieved 22 March 2014.
- ↑ Tumors and Tumorous Conditions of the Bones and Joints by Henry L. Jaffe, Philadelphia, Lea and Febiger 1958