Fibroadenoma pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Pathogenesis
- Fibroadenoma is a common benign tumor of the breast.
- Fibroadenoma arises from connective tissue cells, which are cells that are normally involved in the functional and mechanical support of the surrounding tissues.
- The majority of fibroadenomas are benign and do not demonstrate any malignant potential.
- Fibroadenomas typically contain both stromal and epithelial connective tissue cells.
- Fibroadenoma demonstrate estrogen and progesterone sensitivity and may grow during pregnancy.
- It is thought that the hormone-receptor mechanism mediates the excessive proliferation of epithelial and stromal cells.[1]
- Although fibroadenomas may be develop in any part of the breast, there is a significant predilection for the upper outer quadrant.
Genetics
Associated Conditions
Gross Pathology
- On gross pathology, a painless, firm, solitary, mobile, and slowly growing breast lump is a characteristic finding of fibroadenoma.
- Other charectersitic findings on gross examination of fibroadenoma include:
- Rubbery texture
- Tan/white colored
- Lobulated appearance
- Short slit-like spaces present
- Calcifications
Microscopic Pathology
References
- ↑ Sapino A, Bosco M, Cassoni P, Castellano I, Arisio R, Cserni G; et al. (2006). "Estrogen receptor-beta is expressed in stromal cells of fibroadenoma and phyllodes tumors of the breast". Mod Pathol. 19 (4): 599–606. doi:10.1038/modpathol.3800574. PMID 16554735.