Langerhans cell histiocytosis historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
The clinical presentation of Langerhans cell histiocytosis was first described by Dr. Alfred Hand Jr., an American pediatrician, in 1893.[1] The term histiocytosis X was first used to describe the disease by Dr. Sidney Farber, a pathologist at Boston Children's Hospital, in 1941. The term Langerhans cell histiocytosis was finally agreed upon in 1987 by the the Writing Group of the Histiocyte Society.[2][3]
Historical Perspective
- The clinical presentation of Langerhans cell histiocytosis was first described by Alfred Hand Jr., an American pediatrician, in 1893.[1]
- The term Hand-Schüller-Christian disease was first used to describe the clinical entity following the work of Dr. Artur Schüller and Dr. Henry Christian.[2]
- Between the years 1920 and 1940, Dr. Erich Letterer and Dr. Sture Siwe used the term eosinophilic granuloma (Letterer–Siwe disease) to describe a similar clinical entity of the disease.
- It was not until the year 1941 that Dr. Sidney Farber, a pathologist at Boston Children's Hospital, unified the clinically similar conditions under the term histiocytosis X.
- Following the advances of electron microscopy, the term Birbeck granules was first used to describe the particles found in Langerhan cells in 1961.
- The phagocytic nature of Langerhan cells was first described in 1973 by Dr. Christian Nezelof.[3]
- The term Langerhans cell histiocytosis was finally agreed upon in 1987 by the the Writing Group of the Histiocyte Society.
References
- ↑ 1.0 1.1 DiCaprio MR, Roberts TT (2014). "Diagnosis and Management of Langerhans Cell Histiocytosis". J Am Acad Orthop Surg. 22 (10): 643–652. doi:10.5435/JAAOS-22-10-643. PMID 25281259.
- ↑ 2.0 2.1 Badalian-Very G, Vergilio JA, Fleming M, Rollins BJ (2013). "Pathogenesis of Langerhans cell histiocytosis". Annu Rev Pathol. 8: 1–20. doi:10.1146/annurev-pathol-020712-163959. PMID 22906202.
- ↑ 3.0 3.1 Nezelof C (1979). "Histiocytosis X: a histological and histogenetic study". Perspect Pediatr Pathol. 5: 153–78. PMID 317149.