Sandbox: Langerhans
- Langerhans cell histiocytosis is a rare disease that tends to affect children and adolescents.[1]
- The incidence of Langerhans cell histiocytosis is approximately 5 per 1,000,000 individuals in the United States.
- Langerhans cell histiocytosis commonly affects individuals younger than 15 years of age.
- The median age at diagnosis is depends on the specific subtype of the disease, such as:
- Pulmonary Langerhans cell histiocytosis is usually first diagnosed among adults.
- Unifocal Langerhans cell histiocytosis and multifocal unisystem Langerhans cell histiocytosis are usually first diagnosed among individuals of 2-10 years of age.
- Multifocal multisystem Langerhans cell histiocytosis is usually first diagnosed among individuals younger than 2 years of age.
- Males are more commonly affected with Langerhans cell histiocytosis than females. The male to female ratio is approximately 2 to 1.
- Langerhans cell histiocytosis usually affects Caucasian and Hispanic individuals. African American individuals are less likely to develop Langerhans cell histiocytosis.
- ↑ DiCaprio MR, Roberts TT (2014). "Diagnosis and Management of Langerhans Cell Histiocytosis". J Am Acad Orthop Surg. 22 (10): 643–652. doi:10.5435/JAAOS-22-10-643. PMID 25281259.