Langerhans cell histiocytosis laboratory tests

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Laboratory findings consistent with the diagnosis of Langerhans cell histiocytosis include abnormal complete blood count, erythrocyte sedimentation rate (ESR), basic metabolic panel, and immunohistochemistry.^[1]

Low urine specific gravity (1.008)
Low specific gravity persisted during a water deprivation test
Urine osmolality and urine specific gravity normalize following desmopressin administration