11β-hydroxylase deficiency other diagnostic studies
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Congenital adrenal hyperplasia due to 11β-hydroxylase deficiency Microchapters |
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Differentiating Congenital adrenal hyperplasia due to 11β-hydroxylase deficiency from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Immunohistochemical staining of the adrenal gland may be used for the diagnosis of congenital adrenal hyperplasia due to 11β-hydroxylase deficiency and it demonstrates hyperplasia, poorly defined zonation, and intermingling of the chromaffin and cortical cells.[1]
Other Diagnostic Studies
- Immunohistochemical staining of the adrenal gland may be used in patients with classic 11β-hydroxylase deficiency and it demonstrates:[1]
- Hyperplasia
- Poorly defined zone borders
- Intermingling of the chromaffin and cortical cells
- Amniotic fluid 11-deoxycortisol and oligonucleotide hybridization of deoxyribonucleic acid (DNA) obtained from chorionic villus biopsies.
- DNA analysis
References
- ↑ 1.0 1.1 https://en.wikipedia.org/wiki/Congenital_adrenal_hyperplasia_due_to_21-hydroxylase_deficiency URL Accessed on 10/15/2015