Mesothelioma summary of treatment for peritoneal mesothelioma
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
The types of treatment given are based on the unique needs of the individual with cancer. Peritoneal mesothelioma is a locally aggressive disease that is difficult to treat. The goal of the treatment is to control the disease for as long as possible, manage symptoms, and improve the person’s quality of life.[1]
Treatment for Peritoneal Mesothelioma
There is no established staging system for peritoneal mesothelioma. The types of treatment given are based on the unique needs of the individual with cancer. Peritoneal mesothelioma is a locally aggressive disease that is difficult to treat. The goal of most treatments is to control the disease for as long as possible, manage symptoms, and improve the person’s quality of life.[1]
Surgery
- Surgery is not usually possible for peritoneal mesothelioma because there are often tumors throughout the entire abdomen. However, some individuals with early, localized peritoneal mesothelioma may be offered surgery to remove the entire tumor by peritonectomy.[1]
- Many individuals have advanced peritoneal mesothelioma when they are diagnosed. Surgery may be used to remove as much of the tumor as possible to help relieve symptoms. This type of surgery is called debulking (cytoreductive) surgery. It may be an option for people who are well enough to tolerate surgery.[1]
Chemotherapy
- Chemotherapy may be an option for individuals with advanced peritoneal mesothelioma. Chemotherapy may be given intravenously or intraperitoneal chemotherapy. Intraperitoneal chemotherapy is often the most common way chemotherapy is given to treat peritoneal mesothelioma.[1]
- Individuals having debulking (cytoreductive) surgery for peritoneal mesothelioma may have intraperitoneal chemotherapy at the same time as surgery (hyperthermic intraoperative intraperitoneal chemotherapy or HIIC) or soon after surgery.[1]
Radiation Therapy
- Radiation therapy is not a main treatment for peritoneal mesothelioma, but is sometimes used to relieve symptoms caused by advanced peritoneal mesothelioma (palliative radiation therapy).[1]
Supportive Care
- Peritoneal mesothelioma is often quite advanced when it is diagnosed. Some individuals with very advanced peritoneal mesothelioma may be too ill to have cancer treatments, such as intensive surgery or chemotherapy. They may be offered palliative care treatments to relieve symptoms, such as pain, weight loss, and ascites.[1]
Treatment of Recurrent Peritoneal Mesothelioma
- If peritoneal mesothelioma recurs after it has been treated, treatment options depend on:[1]
- the location of the cancer
- the treatments that have already been used
- the person’s overall health
- Treatment options similar to unresectable peritoneal mesothelioma may be used for recurrent mesothelioma. Chemotherapy may be used to try to shrink or slow the growth of the cancer and relieve symptoms. Radiation therapy and palliative procedures may be used to relieve symptoms.[1]