Primary central nervous system lymphoma history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Primary CNS lymphoma is a primary intracranial tumor usually present in those with severe immunosuppression --- commonly in those with AIDS --- and represents around 20% of all cases of lymphomas in HIV infection (other types being Burkitt's lymphoma and immunoblastic lymphoma).
History
Symptoms
- Symptoms of primary central nervous system lymphoma are identical to the other types of brain tumors and depend on the area of the brain that is affected.[1]
- Primary central nervous system lymphoma is multifocal (tumors in different parts of the brain)
- Symptoms of primary nervous system lymphoma include:[1][2][3]
- Headache
- Nausea
- Vomiting
- Difficulty swallowing
- Double vision
- Monocular vision loss
- Vertigo
- Muscle weakness or paralysis
- Trouble speaking
- Memory loss
- Confusion
- Lethargy
- Progressive dementia or stupor in patients with a nonfocal neurologic exam and minimal abnormalities on MRI (more common in AIDS patients)
- Facial hypoesthesia
- Seizures (uncommon)
- Fever
- Night sweats
- Weight loss
Primary CNS lymphoma usually presents with seizures, headache, cranial nerve findings, altered mental status, or other focal neurological deficits typical of a mass effect[4] [5]. Systemic symptoms may include fever, night sweats, or weight loss.
References
- ↑ 1.0 1.1 Signs and symptoms of primary central nervous system lymphoma. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/primary-cns-lymphoma/?region=on. Accessed on February 17, 2016
- ↑ Signs and symptoms of primary central nervous system lymphoma. Wikipedia 2016. https://en.wikipedia.org/wiki/Primary_central_nervous_system_lymphoma. Accessed on February 18, 2016
- ↑ Ferreri, A. J. M. (2011). "How I treat primary CNS lymphoma". Blood. 118 (3): 510–522. doi:10.1182/blood-2011-03-321349. ISSN 0006-4971.
- ↑ Herrlinger U, Schabet M, Bitzer M, Petersen D, Krauseneck P. Primary central nervous system lymphoma: from clinical presentation to diagnosis. J Neurosurg 2000; 92:261-266
- ↑ Herrlinger U, Schabet M, Bitzer M, Petersen D, Krauseneck P. Primary central nervous system lymphoma: from clinical presentation to diagnosis.J.Neurooncol. 1999;43:219-226. (PMID: 10563426).