Hypergammaglobulinemia pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]

Overview

Hypergammaglobulinemia is an immunoproliferative disorder with elevated levels of gamma globulin (immunoglobulins or antibodies).[1][2]

Pathophysiology

  • Hypergammaglobulinemia is an immunoproliferative disorder which arises from B cells, which are a type of white cells that are normally involved in the development of humoral immunity by secreting antibodies.[3]
  • Hypergammaglobulinemias may be caused by an excess of immunoglobulin M (IgM) or by a deficiency in the other major types of immunoglobulins.[4]

References

  1. Hypergammaglobulinemia. Wikipedia. https://en.wikipedia.org/wiki/Hypergammaglobulinemia Accessed on February 24, 2016.
  2. Globulin. Wikipedia. https://en.wikipedia.org/wiki/Globulin. Wikipedia. Accessed on February 24, 2016.
  3. B cell. Wikipedia. https://en.wikipedia.org/wiki/B_cell Accessed on February 24, 2016.
  4. Immunoproliferative disorder. Wikipedia. Accessed on February 24, 2016.

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