Hypergammaglobulinemia natural history

Jump to navigation Jump to search

Hypergammaglobulinemia Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Hypergammaglobulinemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Hypergammaglobulinemia natural history On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Hypergammaglobulinemia natural history

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Hypergammaglobulinemia natural history

CDC on Hypergammaglobulinemia natural history

Hypergammaglobulinemia natural history in the news

Blogs on Hypergammaglobulinemia natural history

Directions to Hospitals Treating Hypergammaglobulinemia

Risk calculators and risk factors for Hypergammaglobulinemia natural history

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]

Overview

Natural History

Complications

  • Common complications of x-linked hyper-Ig M include:[1]
    • Infection
      • Viral
        • Disseminated cytomegalovirus and herpes simplex virus infections
      • Bacterial
        • Cholangitis from Cryptosporidium parvum
      • Fungal
        • Disseminated
        • Opportunistic Pneumocystis jirovecii pneumonia infections
    • Gastrointestinal tumors
  • The activation-induced cysteine deaminase (AICDA) deficient patients are at an increased risk of developing inflammatory as well as autoimmune diseases like chronic arthritis, autoimmune hemolytic anemia, and autoimmune thrombocytopenia.[2]

Prognosis

References

  1. Fried AJ, Bonilla FA (2009). "Pathogenesis, diagnosis, and management of primary antibody deficiencies and infections". Clin Microbiol Rev. 22 (3): 396–414. doi:10.1128/CMR.00001-09. PMC 2708392. PMID 19597006.
  2. Quartier P, Bustamante J, Sanal O, Plebani A, Debré M, Deville A; et al. (2004). "Clinical, immunologic and genetic analysis of 29 patients with autosomal recessive hyper-IgM syndrome due to Activation-Induced Cytidine Deaminase deficiency". Clin Immunol. 110 (1): 22–9. doi:10.1016/j.clim.2003.10.007. PMID 14962793.

Related Chapters

Template:WikiDoc Sources