Primary cutaneous follicle centre lymphoma medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overvew

The predominant therapy for primary cutaneous follicle centre lymphoma is radiotherapy. Adjunctive chemotherapy may be required.

Medical Therapy

  • Surgical removal and/or radiotherapy is given for localized disease.[1]:314[2]
  • Radiation using multiple radiation fields is given if the disease has wider extent with grouped lesions.[1]:314[3][4][2]
  • For the less common situation of more extensive disease (still confined to skin), rituximab without chemotherapy is used.[1]:314[3][4][2]Intralesional interferon alpha (IFN-α)[5] and intralesional rituximab have been used.[1]:314[5]
  • Approximately one-third of PCFCL relapse, usually in the skin; treatment is similar to initial management[2] and overall survival remains excellent.[6]
A 56-year old male patient with numerous erythematous and livid infiltrates before superficial radiotherapy.[7]
A 56-year old male patient with numerous erythematous and livid infiltrates before superficial radiotherapy.[7]
Post-radiotherapy appearance.[7]
Post-radiotherapy appearance.[7]

References

  1. ↑ 1.0 1.1 1.2 1.3 Invalid <ref> tag; no text was provided for refs named Jaffe_2011_1
  2. ↑ 2.0 2.1 2.2 2.3 Invalid <ref> tag; no text was provided for refs named Wilcox2015
  3. ↑ 3.0 3.1 Invalid <ref> tag; no text was provided for refs named Armitage_2010_2
  4. ↑ 4.0 4.1 Invalid <ref> tag; no text was provided for refs named Sokol2012
  5. ↑ 5.0 5.1 Invalid <ref> tag; no text was provided for refs named Senff2008
  6. ↑ Invalid <ref> tag; no text was provided for refs named Suárez2013_2
  7. ↑ 7.0 7.1 7.2 7.3 Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature. BioMed Central. https://ro-journal.biomedcentral.com/articles/10.1186/1748-717X-8-147. Accessed on March 02, 2016


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