Seminoma pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Gross Pathology
On gross pathology, seminoma is characterized by pale gray to yellow nodules that are uniform or slightly lobulated and often bulge from the cut surface.[1]
Microscopic Pathology
On microscopic pathology, seminoma is characterized by:[2]
- Cells with fried egg appearance - key feature
- Clear cytoplasm
- Central nucleus, with prominent nucleolus. Nucleus may have "corners", i.e. it is not round.
- Lymphoctyes - interspersed (common)
- Syncytiotrophoblasts, present in ~10-20% of seminoma
- Large, irregular, vesicular nuclei
- Eosinophilic vacuolated cytoplasm (contains hCG)
- Florid granulomatous reaction
References
- ↑ Pathology of testicular seminoma. Dr Marcin Czarniecki and Dr Andrew Dixon et al. Radiipaedia 2016. http://radiopaedia.org/articles/testicular-seminoma-1. Accessed on February 29, 2016
- ↑ Microscopic pathology of seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016