Seminoma pathophysiology

Seminoma Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Seminoma from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Staging TNM Stage Grouping
History and Symptoms
Physical Examination
Laboratory Findings
Chest X Ray
CT
MRI
Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy Treatment - Stage I Treatment - Stage II Treatment - Stage III Treatment - Recurrent
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Seminoma pathophysiology On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Seminoma pathophysiology All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Seminoma pathophysiology
CDC on Seminoma pathophysiology
Seminoma pathophysiology in the news
Blogs on Seminoma pathophysiology
Directions to Hospitals Treating Seminoma
Risk calculators and risk factors for Seminoma pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Gross Pathology

On gross pathology, seminoma is characterized by pale gray to yellow nodules that are uniform or slightly lobulated and often bulge from the cut surface.

Microscopic Pathology

• On microscopic pathology, seminoma is characterized by:

• Cells with fried egg appearance - key feature

• Clear cytoplasm
• Central nucleus, with prominent nucleolus. Nucleus may have "corners", i.e. it is not round.

• Lymphocytes - interspersed (common)
• Syncytiotrophoblasts, present in 10-20% of seminoma

• Large, irregular, vesicular nuclei
• Eosinophilic vacuolated cytoplasm (contains hCG)

• Florid granulomatous reaction

• Approximately 24% of Stage I seminomas have lymphovascular invasion for stage I (Tx, N0, M0).
• Intertubular seminoma may not form a discrete mass and mimic a benign testis.

Gallery

• 

  _{Microscopic image of seminoma demonstrating fried egg-like cells (clear or eosinophilic cytoplasm, central nucleus) and lymphocytic infiltrate.}

• 

  _{Very high magnification micrograph of a seminoma with syncytiotrophoblasts on H&E stain. Syncytiotrophoblasts are seen in approximately 10-20% of seminomas. They may be associated with an elevated serum beta-hCG.}

• 

  _{Histopathological image of metastatic seminoma in the inguinal lymph node on hematoxylin & eosin stain.}