Seminoma pathophysiology
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Seminoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Seminoma pathophysiology On the Web |
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American Roentgen Ray Society Images of Seminoma pathophysiology |
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Risk calculators and risk factors for Seminoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Gross Pathology
On gross pathology, seminoma is characterized by pale gray to yellow nodules that are uniform or slightly lobulated and often bulge from the cut surface.[1]
Gallery
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Gross specimen of testicle demonstrating a solid, white/tan mass.
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![Microscopic image of seminoma demonstrating fried egg-like cells (clear or eosinophilic cytoplasm, central nucleus) and lymphocytic infiltrate.[2]](/images/1/1c/800px-Seminoma_high_mag.jpg)
Microscopic image of seminoma demonstrating fried egg-like cells (clear or eosinophilic cytoplasm, central nucleus) and lymphocytic infiltrate.[2]
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![Very high magnification micrograph of a seminoma with syncytiotrophoblasts on H&E stain. Syncytiotrophoblasts are seen in approximately 10-20% of seminomas. They may be associated with an elevated serum beta-hCG.[2]](/images/7/7e/800px-Seminoma_with_syncytiotrophoblasts_-_very_high_mag.jpg)
Very high magnification micrograph of a seminoma with syncytiotrophoblasts on H&E stain. Syncytiotrophoblasts are seen in approximately 10-20% of seminomas. They may be associated with an elevated serum beta-hCG.[2]
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![Histopathological image of metastatic seminoma in the inguinal lymph node on hematoxylin & eosin stain.[2]](/images/f/f6/Testicular_seminoma_%281%29_nodal_metastasis.jpg)
Histopathological image of metastatic seminoma in the inguinal lymph node on hematoxylin & eosin stain.[2]
![Microscopic image of seminoma demonstrating fried egg-like cells (clear or eosinophilic cytoplasm, central nucleus) and lymphocytic infiltrate.[2]](/index.php/File:800px-Seminoma_high_mag.jpg)
![Very high magnification micrograph of a seminoma with syncytiotrophoblasts on H&E stain. Syncytiotrophoblasts are seen in approximately 10-20% of seminomas. They may be associated with an elevated serum beta-hCG.[2]](/index.php/File:800px-Seminoma_with_syncytiotrophoblasts_-_very_high_mag.jpg)
![Histopathological image of metastatic seminoma in the inguinal lymph node on hematoxylin & eosin stain.[2]](/index.php/File:Testicular_seminoma_(1)_nodal_metastasis.jpg)
Immunohistochemistry
Seminoma is demonstrated by positivity to tumor markers, such as:[3]
References
- ↑ Pathology of testicular seminoma. Dr Marcin Czarniecki and Dr Andrew Dixon et al. Radiipaedia 2016. http://radiopaedia.org/articles/testicular-seminoma-1. Accessed on February 29, 2016
- ↑ 2.0 2.1 2.2 Microscopic pathology of seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016
- ↑ IHC for seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016