Primary cutaneous follicle centre lymphoma overview
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Primary cutaneous follicle centre lymphoma Microchapters |
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Differentiating Primary cutaneous follicle centre lymphoma from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Primary cutaneous follicle center lymphoma (PCFCL) can be defined as neoplastic proliferation of the follicle germinal center cells limited to the skin. PCFCL is a primary cutaneous B-cell lymphoma composed of neoplastic B-cells with morphological and immunophenotypic properties of follicle center cells, usually a combination of centrocytes (small and large cleaved center cells) and a variable number of centroblasts (large noncleaved follicle center cells with prominent nucleoli). According to growth pattern, it is divided into follicular, diffuse and mixed pattern.