Osteomyelitis historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nate Michalak, B.A.
Overview
Historical Perspective
- Osteomyelitis has been identified in the fractured spine of a dimetrodon Permian reptile, which existed 291 to 250 million years ago.
- Osteomyelitis may have been been first described by Hippocrates (460-370 BC).
- Before Auguste Nelation termed the disease "osteomyelitis" in 1844, the disease was referred to as "abscessus in medulla", "necrosis" and "boil of the bone marrow".
- Prior to the introduction of penicillin in 1940 as an antibiotic, osteomyelitis was usually treated with crude surgical excision of necrotic tissue or limb amputation.
- Penicillin significantly reduced mortality until 1950, after the emergence of penicillin-resistant bacteria, most commonly Staphylococcus.
- In 1970, NJ Blockey, JT Watson, and TA McAllister reevaluated the treatment of osteomyelitis with antibiotics and surgery, which reflects current clinical practices.