Gonadoblastoma

WikiDoc Resources for Gonadoblastoma
Articles
Most recent articles on Gonadoblastoma Most cited articles on Gonadoblastoma Review articles on Gonadoblastoma Articles on Gonadoblastoma in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Gonadoblastoma Images of Gonadoblastoma Photos of Gonadoblastoma Podcasts & MP3s on Gonadoblastoma Videos on Gonadoblastoma
Evidence Based Medicine
Cochrane Collaboration on Gonadoblastoma Bandolier on Gonadoblastoma TRIP on Gonadoblastoma
Clinical Trials
Ongoing Trials on Gonadoblastoma at Clinical Trials.gov Trial results on Gonadoblastoma Clinical Trials on Gonadoblastoma at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Gonadoblastoma NICE Guidance on Gonadoblastoma NHS PRODIGY Guidance FDA on Gonadoblastoma CDC on Gonadoblastoma
Books
Books on Gonadoblastoma
News
Gonadoblastoma in the news Be alerted to news on Gonadoblastoma News trends on Gonadoblastoma
Commentary
Blogs on Gonadoblastoma
Definitions
Definitions of Gonadoblastoma
Patient Resources / Community
Patient resources on Gonadoblastoma Discussion groups on Gonadoblastoma Patient Handouts on Gonadoblastoma Directions to Hospitals Treating Gonadoblastoma Risk calculators and risk factors for Gonadoblastoma
Healthcare Provider Resources
Symptoms of Gonadoblastoma Causes & Risk Factors for Gonadoblastoma Diagnostic studies for Gonadoblastoma Treatment of Gonadoblastoma
Continuing Medical Education (CME)
CME Programs on Gonadoblastoma
International
Gonadoblastoma en Espanol Gonadoblastoma en Francais
Business
Gonadoblastoma in the Marketplace Patents on Gonadoblastoma
Experimental / Informatics
List of terms related to Gonadoblastoma

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Your Name

Synonyms and keywords: Synonym 1; Synonym 2; Synonym 3

Historical Perspective

• Gonadoblastoma was first discovered by Scully, in 1953.

Pathophysiology

• A gonadoblastoma is a complex neoplasm composed of a mixture of gonadal elements, such as large primordial germ cells, immature Sertoli cells or granulosa cells of the sex cord, and gonadal stromal cells.
• Abnormal chromosomal karyotype, gonadal dysgenesis, and the presence of a Y chromosome has been associated with the development of gonadoblastoma.

Causes

• Gonadoblastoma may be caused by either complete androgen insensitivity, pure gonadal dysgenesis or Swyer syndrome, mixed gonadal dysgenesis, Frasier syndrome, Denys-Drash syndrome, and 9p Partial monosomy.

Differentiating Gonadoblastoma from other Diseases

• Gonadoblastoma must be differentiated from other diseases that cause ovarian tumors, such as:

• Germinoma
• Cystadenoma
• Cystadenocarcinoma
• Endometrioid tumor
• Brenner tumor
• Leydig cell tumor
• Granulosa cell tumor
• 17-Hydroxylase Deficiency Syndrome
• 5-Alpha-Reductase Deficiency
• Amenorrhea
• Congenital Adrenal Hyperplasia
• Genital Anomalies
• Hypospadias
• Pediatric Seminoma
• Turner Syndrome
• Meigs syndrome

Other Diagnostic Studies

• Gonadoblastoma may also be diagnosed using chromosomal analysis.

Treatment

Surgery

• Surgery is the mainstay of therapy for gonadoblastoma.
• Surgical exploration via laparotomy and bilateral salpingo-oophorectomy (BSO) is the most common approach to the treatment of gonadoblastoma.