Alpha 1-antitrypsin deficiency laboratory tests

Alpha 1-antitrypsin deficiency Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Alpha 1-antitrypsin deficiency from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications, and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X Ray
CT
MRI
Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Alpha 1-antitrypsin deficiency laboratory tests On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Alpha 1-antitrypsin deficiency laboratory tests All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Alpha 1-antitrypsin deficiency laboratory tests
CDC on Alpha 1-antitrypsin deficiency laboratory tests
Alpha 1-antitrypsin deficiency laboratory tests in the news
Blogs on Alpha 1-antitrypsin deficiency laboratory tests
Directions to Hospitals Treating Alpha 1-antitrypsin deficiency
Risk calculators and risk factors for Alpha 1-antitrypsin deficiency laboratory tests

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

Laboratory Findings

The diagnosis of alpha-1 AT deficiency should be suspected in any patient who:

1. Develops emphysema younger than 45 years old, if they are a non/minimal smoker, or if they have primarily basilar disease OR
2. Has a history of panniculitis or
3. Has or has a family history of unexplained liver disease (especially cirrhosis or hepatoma).
   

• In suspected individuals the initial step is to measure the serum alpha-1 AT concentration.
• In general, phenotyping should be reserved for patients who have low or borderline low alpha-1 AT levels.
• PFTs-pulmonary function tests (spirometry pre and post bronchodilators, lung volumes and diffusing capacity),
• LFTs (liver function test)
• ABG-arterial blood gases (usually)

References

Template:WikiDoc Sources