Thrombophilia natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Asiri Ediriwickrema, M.D., M.H.S. [2]
Overview
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Natural History
Complications
Thrombophilic state | Thrombotic risk[1] |
---|---|
Trauma/General surgery | Modest |
Age > 60 | Modest |
Immobilization | Modest |
Pregnancy | Modest |
Hormone therapies | Modest |
Factor V Leiden heterozygosity | Modest |
Prothrombin mutation | Modest |
Homocysteinemia | Modest |
Increased factor VIII levels | Modest |
Increased factor IX levels | Modest |
Increased factor XI levels | Modest |
Protein C and S deficiency | Intermediate |
Dysfibrogenemia | Intermediate |
Malignancy | High |
APLS/Lupus anticoagulant | High |
Myeloproliferative disorders/hyperviscosity | High |
PNH | High |
Orthopedic surgery | High |
Antithrombin deficiency | High |
Factor V Leiden homozygosity | High |
Prognosis
References
- ↑ Bates SM, Ginsberg JS (2004). "Clinical practice. Treatment of deep-vein thrombosis". N Engl J Med. 351 (3): 268–77. doi:10.1056/NEJMcp031676. PMID 15254285.