Drug induced liver injury prevention

Drug induced liver injury Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rachita Navara, M.D. [2]

Overview

Given that many cases of drug induced liver injury are idiosyncratic, it is often not possible to prevent injury.

Primary Prevention

Patient education on drug-drug interactions and safe dosing is recommended to prevent liver injury from known hepatotoxic drugs (e.g. acetaminophen). However, screening with routine serum alanine aminotransferase monitoring is controversial.

Secondary Prevention

Secondary prevention strategies following drug induced liver injury include prompt withdrawal of the inciting drug, which is also the mainstay of treatment for this disease.