Erysipeloid
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Prince Tano Djan, BSc, MBChB [2] Faizan Sheraz, M.D. [3]
Synonyms and Keywords: Erysipelotrichosis, Rose fish-handlers disease, Rosenbach's disease, Rosenbach's Erysipeloid or Erysipeloid of Rosenbach.
| Erysipeloid | |
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| Cellular and colonial morphology of Erysipelothrix rhusiopathiae | |
| ICD-10 | A26 |
| ICD-9 | 027.1 |
| DiseasesDB | 4432 |
| MedlinePlus | 000632 |
| eMedicine | derm/602 |
| MeSH | D004887 |
Overview
Erysipeloid is an occupational infection of the skin caused by traumatic penetration of Erysipelothrix rhusiopathiae (formerly E. insidiosa). The disease is characterized clinically by an erythematous edema, with well-defined and raised borders, usually localized to the back of one hand and/or fingers. Vesicular, bullous, and erosive lesions may also be present. The lesion may be asymptomatic or accompanied by mild pruritus, pain and fever. In addition to cutaneous infection, E. rhusiopathiae can cause endocarditis, which may be acute or subacute. Endocarditis is rare and has a male predilection. It usually occurs in previously damaged valves, predominantly the aortic valve. Endocarditis does not occur in patients with valvular prostheses and is not associated with intravenous drug misuse. Diagnosis of localized erysipeloid is based on the patient's history (occupation, previous traumatic contact with infected animals or their meat) and clinical picture (typical skin lesions, lack of severe systemic features, slight laboratory abnormalities and rapid remission after treatment with penicillin or cephalosporin).
In humans, Erysipelothrix rhusiopathiae infections most commonly present in a mild cutaneous form known as erysipeloid[1] or fish poisoning.[2] E. rhusiopathiae can cause an indolent cellulitis, more commonly in individuals who handle fish and raw meat.[3] It gains entry typically by abrasions in the hand. Bacteremia and endocarditis are uncommon but serious sequelae.[4][5] Due to the rarity of reported human cases, E. rhusiopathiae infections are frequently misidentified at presentation.[1]
Historical Perspective
In 1884, Friedrich Julius Rosenbach, also called Anton Julius Friedrich Rosenbach, a German physician and microbiologist was the first to accurately discover the association between Erysipelothrix rhusiopathiae and development of Erysipeloid. Erysipelothrix rhusiopathiae was first isolated from mice in 1880 by Koch in 1880. [6][7]
Classification
Erysipeloid may be classified into the following categories according to the severity of the condition:[7]
Localized cutaneous erysipeloid
- Usually a mild, localized infection
- Patients present with local swelling and redness of the skin
- Popularly referred to as "erysipeloid of Rosenbach"
Diffuse cutaneous Erysipeloid
- May present with fever.
Generalized or systemic Erysipeloid
- Manifests as bacterimia with associated complications (e.g., endocarditis, arthritis)
Pathophysiology
Pathogenesis
Development of Erysipeloid is the result of an infection with Erysipelothrix rhusiopathiae; after a traumatized skin of a person comes into contact with a contaminated fish, poultry or raw meat.[8] Erysipelothrix rhusiopathiae, which is highly resistant to environmental factors[7], enters the skin through scratches or pricks. Various virulence factors have been suggested as being involved in the pathogenicity of Erysipeloid. Following infection in the skin, the organism produces certain enzymes that help it dissect its way through the tissues. Significant among them are hyaluronidase and neuraminidase[8]. It has been shown that neuraminidase plays a significant role in the attachment of Erysipelothrix rhusiopathiae and subsequent invasion into host cells. The role of hyaluronidase in the disease process is controversial. The presence of a heat labile capsule has been reported as important in virulence[8]. It has been discovered that only pathogenic strains of [[Erysipelothrix rhusiopathiae] are capable of producing the neuraminidase enzyme. In addition, two adhesive surface proteins named RspA and RspB also serve in helping the microorganism bind to collagen (types I and IV) and polystyrene surfaces. Meanwhile, the host's immune system is activated to start fighting against this foreign bacterium. The organism may escape immune surveillance and may spread in the body via the vascular system to the joints, heart, brain, kidney, CNS, and lungs. The organ most commonly affected other than the skin is the heart.
Associated conditions
The following conditions has been associated with erysipeloid:
- Endocarditis[8][9][10][11]
- Hodgkins lymphoma[12]
- Use of Gemcitabine[8]
- Sweet's syndrome[13]
- renal failure[10]
- septic arthritis[10]
- polyarthralgia[10]
Causes
Erysipeloid is caused by an infection with Erysipelothrix rhusiopathiae; a Gram-positive, catalase-negative, rod-shaped, non-spore-forming, non-acid-fast, non-motile bacterium after a traumatized skin of a person comes into contact with a contaminated fish, poultry or raw meat. [7][8][10][11]
Differentiating Erysipeloid from Other Diseases
Erysipeloid must be differentiated from other conditions as follows:
Epidemiology and Demographics
Infection with E rhusiopathiae occurs in worldwide distribution in a variety of animals, examples include; sheep, rabbit, turkey, birds, cattle, rats and fish [6]
Race
No racial predilection is recognized for erysipeloid.
Sex
Both sexes may be equally affected; however, erysipeloid seems to affect more males than females because of occupational exposure.
Age
Erysipeloid can affect any age group.
Risk Factors
Erysipeloid is most common among individuals who have direct contact with infected animals. The following are among those at highest risk for the condition [6].:*
- Fishermen
- Farmers
- Slaughterhouse workers
- Butchers
- Meat handlers
- Agricultural workers
Erysipeloid is seen most frequently during the summer or early fall.[7]
Screening
There is no screening modality for erysipeloid.[6]
Natural History, Complications, and Prognosis
The local and cutaneous forms of the disease are usually self-limiting and may resolve spontaneously[11]. In individuals receiving appropriate antibiotic treatment, the prognosis for complete recovery is excellent. In those who are not treated adequately, endocarditis or arthritis may develop, but these conditions are not usually severe and can be effectively treated. Needle aspiration of an infected joint, possibly repeated on multiple occasions, will, in conjunction with antibiotic therapy, lead to resolution of the arthritis.
Antibiotic-resistant strains will complicate therapy. Repeated infection may result in the development of allergic sensitivities. Reduced immunity may complicate the infection. Individuals with the severe systemic form may have irreversible neurological damage. Endocarditis may result in long-term valvular heart disease. Septic arthritis may result in long-term joint disease.
Diagnosis
History and Symptoms
A person with erysipeloid infection usually presents with a history of an occupation requiring handling of unprocessed meat or fish. Symptoms may include skin irritations either of the localized or the diffuse form. Individuals may report burning, itching, or pain. If systemic infection is present, symptoms may include fever, chills, fatigue, or malaise[14]
Physical Examination
On physical examination the affected area usually shows bright red-to-purple, nonvesiculated, maculopapular plaques with a smooth, shiny surface, typically found on the webs of the fingers, hands, or forearms; the lesions are clearly defined, raised, and indurated. The rash or lesions may be warm and/or tender. Fever is occasionally present. Individuals with joint involvement may have swelling of some joints. Individuals with endocarditis may have a heart murmur noted on examination.[14].
Laboratory Findings
Laboratory investigations are usually not need to make diagnosis of erysipeloid since the diagnosis is mostly clinical. However, cuture of a specimen from drainage from the infected area may yield the diagnosis. Sometimes, a full-thickness biopsy culture is needed to make the diagnosis. Blood culture is necessary for the diagnosis of erysipeloid endocarditis.
Imaging Findings
CT scan may be helpful in the diagnosis of erysipeloid endocarditis. CT scan may show vegetations, paravalvular abscesses, and pseudoaneurysms.
Treatment
Medical Therapy
The treatment of choice is a single dose of benzathine benzylpenicillin given by intramuscular injection, or a five-day to one-week course of either oral penicillin or intramuscular procaine benzylpenicillin.[11][7][15] Erythromycin or doxycycline may be given instead to people who are allergic to penicillin. E. rhusiopathiae is intrinsically resistant to vancomycin.[15]
Surgery
Surgery is usually not necessary. However, in rare cases with massive valvular destruction complicating endocarditis, surgical valvular replacement may be needed.[16]
Prevention
Primary prevention
Effective measures for the primary prevention of erysipeloid include [6]:
- Individuals whose work include meat handling, fishing, and agricultural jobs should wear protective gloves when possible to avoid infection with contaminated food.
- Individuals with erysipeloid should be restricted from handling meat or fish products until the infection is cured.
Secondary Prevention
There are no secondary preventive measures available for erysipeloid.
Antimicrobial Regimen
- Preferred regimen (1): Penicillin 500 mg qid for 7–10 days
- Preferred regimen (2): Amoxicillin 500 mg tid for 7–10 days
- Erysipelothrix rhusiopathiae [17]
- 1. Erysipeloid of Rosenbach (localized cutaneous infection)
- Preferred regimen (1): Penicillin G benzathine 1.2 MU IV single dose
- Preferred regimen (2): Penicillin VK 250 mg PO qid for 5-7 days
- Preferred regimen (3): Procaine penicillin 0.6-1.2 MU IM qd for 5-7 days
- Alternative regimen (1): Erythromycin 250 mg PO qid for 5-7 days
- Alternative regimen (2): Doxycycline 100 mg PO bid for 5-7 days
- 2. Diffuse cutaneous infection
- Preferred regimen: See localized infection
- 3. Bacteremia or endocarditis
- Preferred regimen: Penicillin G benzathine 2-4 MU IV q4h for 4-6 weeks
- Alternative regimen (1): Ceftriaxone 2 g IV q24h for 4-6 weeks
- Alternative regimen (2): Imipenem 500 mg IV q6h for 4-6 weeks
- Alternative regimen (3): Ciprofloxacin 400 mg IV q12h for 4-6 weeks
- Alternative regimen (4): Daptomycin 6 mg/kg IV q24h for 4-6 weeks
- Note: Recommended duration of therapy for endocarditis is 4 to 6 weeks, although shorter courses consisting of 2 weeks of intravenous therapy followed by 2 to 4 weeks of oral therapy have been successful.
See also
References
- ↑ 1.0 1.1 Brooke C, Riley T (1999). "Erysipelothrix rhusiopathiae: bacteriology, epidemiology and clinical manifestations of an occupational pathogen". J Med Microbiol. 48 (9): 789–99. doi:10.1099/00222615-48-9-789. PMID 10482289.
- ↑ "THE SHIP CAPTAIN'S MEDICAL GUIDE" (PDF). p. 190.
- ↑ Lehane L, Rawlin G (2000). "Topically acquired bacterial zoonoses from fish: a review". Med J Aust. 173 (5): 256–9. PMID 11130351.
- ↑ Brouqui P, Raoult D (2001). "Endocarditis due to rare and fastidious bacteria". Clin Microbiol Rev. 14 (1): 177–207. doi:10.1128/CMR.14.1.177-207.2001. PMC 88969. PMID 11148009.
- ↑ Nassar I, de la Llana R, Garrido P, Martinez-Sanz R (2005). "Mitro-aortic infective endocarditis produced by Erysipelothrix rhusiopathiae: case report and review of the literature". J Heart Valve Dis. 14 (3): 320–4. PMID 15974525.
- ↑ 6.0 6.1 6.2 6.3 6.4 Mandell, Gerald (1985). principles and practice of infectious diseases. New York: John Wiley & sons. p. 1185. ISBN 0-471-87643-7.
- ↑ 7.0 7.1 7.2 7.3 7.4 7.5 Brooke CJ, Riley TV (1999). "Erysipelothrix rhusiopathiae: bacteriology, epidemiology and clinical manifestations of an occupational pathogen". J Med Microbiol. 48 (9): 789–99. doi:10.1099/00222615-48-9-789. PMID 10482289.
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 Wang Q, Chang BJ, Riley TV (2010). "Erysipelothrix rhusiopathiae". Vet Microbiol. 140 (3–4): 405–17. doi:10.1016/j.vetmic.2009.08.012. PMID 19733019.
- ↑ Foster JD, Hartmann FA, Moriello KA (2012). "A case of apparent canine erysipeloid associated with Erysipelothrix rhusiopathiae bacteraemia". Vet Dermatol. 23 (6): 528-e108. doi:10.1111/j.1365-3164.2012.01115.x. PMID 23140319.
- ↑ 10.0 10.1 10.2 10.3 10.4 Dunbar SA, Clarridge JE (2000). "Potential errors in recognition of Erysipelothrix rhusiopathiae". J Clin Microbiol. 38 (3): 1302–4. PMC 88613. PMID 10699048.
- ↑ 11.0 11.1 11.2 11.3 Boyd AS, Ritchie C, Fenton JS (2014). "Cutaneous Erysipelothrix rhusiopathiae (erysipeloid) infection in an immunocompromised child". Pediatr Dermatol. 31 (2): 232–5. doi:10.1111/j.1525-1470.2012.01835.x. PMID 22957967.
- ↑ Mazellier S, Hubiche T, Weinbreck N, Gutnecht J, Del Giudice P (2014). "Erysipeloid Hodgkin lymphoma". Eur J Dermatol. 24 (4): 513–4. doi:10.1684/ejd.2014.2392. PMID 25118689.
- ↑ Chaabane H, Amouri M, Meziou TJ, Dammak A, Bouassida S, Boudawara T; et al. (2014). "[Sweet's syndrome: a rare cause of erysipeloid dermatitis]". Tunis Med. 92 (10): 649–50. PMID 25860686.
- ↑ 14.0 14.1 Veraldi S, Girgenti V, Gianotti R (2009). "Erysipeloid". Clin Exp Dermatol. 34 (8): e605–7. doi:10.1111/j.1365-2230.2009.03292.x. PMID 19486064.
- ↑ 15.0 15.1 Vinetz J (October 4, 2007). "Erysipelothrix rhusiopathiae". Point-of-Care Information Technology ABX Guide. Johns Hopkins University. Retrieved on October 28, 2008. Freely available with registration.
- ↑ Rocha MP, Fontoura PR, Azevedo SN, Fontoura AM (1989). "Erysipelothrix endocarditis with previous cutaneous lesion: report of a case and review of the literature". Rev Inst Med Trop Sao Paulo. 31 (4): 286–9. PMID 2697071.
- ↑ Bartlett, John (2012). Johns Hopkins ABX guide : diagnosis and treatment of infectious diseases. Burlington, MA: Jones and Bartlett Learning. ISBN 978-1449625580.