Erythrasma pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Luke Rusowicz-Orazem, B.S.
Overview
Pathophysiology
Pathogenesis
- Erythrasma develops when Corynebacterium minitissium infiltrates the stratum corneum and proliferate.[1]
- The bacteria proliferates on the epidermis and develops at the intracellular level of the stratum corneum.
- Penetration of the skin occurs when the horny cells of the plasma membranes rupture .
- Keratolysis occurs due to the removal of keratin fibrils from the bacteria, leading to the formation of reddish-brown lesions characteristic of Erythrasma.
- The exact cause, chemical or systemic, of the keratolysis is unknown.[2]
Microscopic Pathology
- Erythrasma presents with the following microscopic findings:[1]
- Thickening of stratum corneum without signs of parakeratosis
- Largest concentration of Corynebacterium minitissium in the upper third of the stratum corneum
- Widening of intracelluar space, allowing bacterial invasion, and separation of the horny cells
- Disappearance of plasma cell membranes at the sites of Corynebacterium minitissium infiltration.
- Decreased electron density around intracellular bacteria and those in direct contact with the cell wall
References
- ↑ 1.0 1.1 Montes, Leopoldo F.; Black, S.H.; McBride, Mollie E. (1967). "Bacterial Invasion of the Stratum Corneum in Erythrasma". Journal of Investigative Dermatology. 49 (5): 474–485. doi:10.1038/jid.1967.168. ISSN 0022-202X.
- ↑ Raubitschek, F. (1962). "Mechanical versus chemical keratolysis by dermatophytes". Medical Mycology. 1 (2): 87–90. doi:10.1080/00362176285190191. ISSN 1369-3786.