Erythrasma medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2] Maliha Shakil, M.D. [3] Kalsang Dolma, M.B.B.S.[4] Luke Rusowicz-Orazem, B.S.
Overview
Antimicrobial therapy is indicated in erythrasma. Patients with localized infection are treated with Clindamycin and patients with widespread infection are treated with either Clarithromycin or Erythromycin.
Medical Therapy
The mainstay of Erythrasma medical therapy is topical and systemic antibiotic therapy. The primary antibiotics used for local and widespread infection include clindamycin, clarithromycin, and erythromycin, respectively. Additionally, there are studies that display efficacy of topical fusidic acid
Antibiotic Regimen
- Erythrasma[1]
- Localized infection
- Preferred regimen: Fusidic acid Topical bid or tid for 7-14 days
- Alternative regimen : Clindamycin Topical bid or tid for 7-14 days
- Widespread infection
- Preferred regimen (1): Clarithromycin 500 mg PO bid for 14 days
- Preferred regimen (2): Erythromycin 250 mgA PO bid for 14 days
- Alternative regimen (1): Tetryacycline 250 mgA PO bid for 14 days[2]
- Alternative regimen (2): Chloramphenicol 250 mgA PO bid for 14 days
- Administration of chloramphenicol is limited due to its suppression of bone marrow and heightening risk of developing neutropenia, agranulocytosis and aplastic anaemia.[2]
- Localized infection
- Studies have revealed efficacy in topical fusidic acid Erythrasma treatment.[3]
- There is evidence that fusidic acid therapy is more effective than topical clarithromycin and systemic erythromycin, but may be indicated less due to poorer efficiency and patient compliance.[4]
References
- ↑ Gilbert, David (2015). The Sanford guide to antimicrobial therapy. Sperryville, Va: Antimicrobial Therapy. ISBN 978-1930808843.
- ↑ 2.0 2.1 Holdiness MR (2002). "Management of cutaneous erythrasma". Drugs. 62 (8): 1131–41. PMID 12010076.
- ↑ Hamann K, Thorn P (1991). "Systemic or local treatment of erythrasma? A comparison between erythromycin tablets and Fucidin cream in general practice". Scand J Prim Health Care. 9 (1): 35–9. PMID 2041927.
- ↑ Avci O, Tanyildizi T, Kusku E (2013). "A comparison between the effectiveness of erythromycin, single-dose clarithromycin and topical fusidic acid in the treatment of erythrasma". J Dermatolog Treat. 24 (1): 70–4. doi:10.3109/09546634.2011.594870. PMID 21923567.