Hepatitis B differential diagnosis
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Hepatitis B |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
Hepatitis B must be differentiated from other diseases that cause fever, nausea, vomiting, jaundice, hepatomegaly, icteric sclera, elevated ALT, AST, such as other viral hepatitis, alcoholic hepatitis, and autoimmune hepatitis.[1][2][3]
Differentiating Hepatitis B from other Diseases
Shown below is a table that summarizes the findings that differentiate hepatitis B from other conditions that cause fever, nausea, vomiting, jaundice, hepatomegaly, and icteric sclera.[1][2][3][4][5][6][7]
| Disease | Findings |
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| Viral Hepatitis A |
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| Viral Hepatitis C |
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| Viral Hepatitis D |
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| Viral Hepatitis E |
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| Alcoholic Hepatitis | Symptoms are similar to the ones of hepatitis B, however, alcoholic hepatitis is related to the excessive use of alcohol. Alcoholic hepatitis presents more often with ascites. Alcoholic hepatitis often leads to cirrhosis and liver failure, if alcohol use is not decreased. Serologic testing will help differentiate these two conditions. Also laboratory results show ALT<AST in alcoholic hepatitis (inverse from viral hepatitis, which is ALT>AST). |
| Autoimmune Hepatitis | Autoimmune hepatitis occurs when the body's immune system attacks the hepatocytes. It often affects young females and may present with signs of acute hepatitis or chronic liver disease. Serologic testing will help differentiate these two conditions. |
References
- ↑ 1.0 1.1 Centers for Disease Control and Prevention. Viral Hepatitis http://www.cdc.gov/hepatitis/ Accessed on October 4th, 2016
- ↑ 2.0 2.1 Cohen JA, Kaplan MM (1979). "The SGOT/SGPT ratio--an indicator of alcoholic liver disease". Dig Dis Sci. 24 (11): 835–8. PMID 520102.
- ↑ 3.0 3.1 Williams AL, Hoofnagle JH (1988). "Ratio of serum aspartate to alanine aminotransferase in chronic hepatitis. Relationship to cirrhosis". Gastroenterology. 95 (3): 734–9. PMID 3135226.
- ↑ Centers for Disease Control and Prevention. Viral Hepatitis http://www.cdc.gov/hepatitis/ Accessed on October 4th, 2016
- ↑ World Health Organization, Guidelines for the screening care and treatment of persons with hepatitis C infection. (2015). http://apps.who.int/iris/bitstream/10665/111747/1/9789241548755_eng.pdf?ua=1&ua=1 Accessed on October 5th, 2016
- ↑ Centers for Disease Control and Prevention. MMWR. Prevention of Hepatitis A Through Active or Passive Immunization Recommendations of the Advisory Committee on Immunization Practices (ACIP) (2006). http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5507a1.htmAccessed on October 5th, 2016
- ↑ Buti M, Esteban R, Jardi R, Rodriguez-Frias F, Casacuberta J, Esteban JI; et al. (1989). "Chronic delta hepatitis: detection of hepatitis delta virus antigen in serum by immunoblot and correlation with other markers of delta viral replication". Hepatology. 10 (6): 907–10. PMID 2583685.