Splenomegaly causes

Template:Splenomegaly Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Causes

Causes in Alphabetical Order

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Less common causes

• Amyloidosis
• Babesiosis
• Gaucher's disease
• Histoplasmosis
• Kala-azar
• Rickets
• Schistosomiasis
• Syphilis
• Toxoplasmosis
• Typhoid fever

Causes by Organ System

Splenomegaly grouped on the basis of the pathogenic mechanism

Increased function	Abnormal blood flow	Infiltration
Removal of defective RBCs Spherocytosis Thalassemia Hemoglobinopathies Nutritional anemias early sickle cell anemia Immune hyperplasia Response to infection (viral,bacterial,fungal,parasitic) Mononucleosis, AIDS, Viral hepatitis Subacute bacterial endocarditis, bacterial septicemia Splenic abscess, Typhoid fever brucellosis,Leptospirosis, tuberculosis Histoplasmosis Malaria, leishmaniasis, trypanosomiasis Ehrlichiosis Disordered immunoregulation Rheumatoid arthritis SLE Serum sickness Autoimmune hemolytic anemia Immune thrombocytopenia Sarcoidosis Drug reactions Extramedullary hematopoiesis Myelofibrosis Marrow infiltration by tumors, leukemias marrow damage by radiation, toxins	Organ Failure Cirrhosis congestive heart failure Vascular Hepatic vein obstruction Portal vein obstruction Budd-Chiari syndrome Splenic vein obstruction Infections Hepatic schistosomiasis Hepatic echinococcosis	Metabolic diseases Gauchers disease Niemann-Pick disease Hurler syndrome and other Mucopolysaccharidoses Amyloidosis Tangier disease Benign and malignant infiltrations Leukemias(acute, chronic, lymphoid and myeloid) Lymphomas (Hodgkins and non-hodgkins) Myeloproliferative disorders Metastatic tumors(commonly melanoma) Histiocytosis X Hemangioma,Lymphangioma Splenic cysts Hamartomas Eosinophilic granuloma

Causes of Massive Splenomegaly (>1000gms)

• Autoimmune hemolytic anemia
• Chronic lymphocytic leukemia
• Chronic myelogenous leukemia
• Gauchers disease
• Hairy cell leukemia
• Kala-Azar (Leishmaniasis)
• Lymphomas
• Malaria
• Myelofibrosis
• Polycythemia vera
• Portal hypertension of Bilharziasis
• Sarcoidosis
• Thalassemia