Granulomatosis with polyangiitis differential diagnosis
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Differentiating Granulomatosis with polyangiitis from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]
Overview
Granulomatosis with polyangiitis must be differentiated from other diseases that cause purpura, alveolar hemorrhage, necrotizing extra-capillary glomerulonephritis, such as Microscopic polyangiitis and Eosinophilic granulomatosis with polyangiitis.[1]
Differentiating Wegener's Granulomatosis from other Diseases
Granulomatosis with polyangiitis must be differentiated from other diseases that cause purpura, alveolar hemorrhage, necrotizing extra-capillary glomerulonephritis, such as Microscopic polyangiitis and Eosinophilic granulomatosis with polyangiitis.[1]
Differentiating Granulomatosis with polyangiitis from Other Diseases
Granulomatosis with polyangiitis must be differentiated from other disease that cause purpura, alveolar hemorrhage, necrotizing extra-capillary glomerulonephritis and include:[1]
- mononeuritis multiplex
- venous thrombosis
- necrotizing vasculitis of small-sized vessels
Differential diagnosis (alternative possible diagnoses) can be extensive. ANCAs can be positive after the use of certain drugs, and other forms of vasculitis can present with very similar symptoms. The saddle nose deformity may also seen in cocaine abuse and in congenital syphilis.
References
- ↑ 1.0 1.1 1.2 Pagnoux C (2016). "Updates in ANCA-associated vasculitis". Eur J Rheumatol. 3 (3): 122–133. doi:10.5152/eurjrheum.2015.0043. PMID 27733943.