Granulomatosis with polyangiitis laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]

Overview

Work-Up

Blood Work-Up

Urianlysis

Renal Biopsy & Electron Microscopy

Renal biopsy is the gold standard in establishing Granulomatosis with polyangiitis.^[1] Renal biopsy reveals under electron microscopy subendothelial edema, microthrombosis, and degranulation of neutrophils. Under light microscopy, necrotizing and crescentic glomerulonephritis is seen. ^[2]

References

↑ Berden AE, Ferrario F, Hagen EC, Jayne DR, Jennette JC, Joh K; et al. (2010). "Histopathologic classification of ANCA-associated glomerulonephritis". J Am Soc Nephrol. 21 (10): 1628–36. doi:10.1681/ASN.2010050477. PMID 20616173.
↑ Bajema IM, Hagen EC, Ferrario F, de Heer E, Bruijn JA (2001). "Immunopathological aspects of systemic vasculitis". Springer Semin Immunopathol. 23 (3): 253–65. PMID 11591101.

[pmid20616173-1] Berden AE, Ferrario F, Hagen EC, Jayne DR, Jennette JC, Joh K; et al. (2010). "Histopathologic classification of ANCA-associated glomerulonephritis". J Am Soc Nephrol. 21 (10): 1628–36. doi:10.1681/ASN.2010050477. PMID 20616173.

[pmid11591101-2] Bajema IM, Hagen EC, Ferrario F, de Heer E, Bruijn JA (2001). "Immunopathological aspects of systemic vasculitis". Springer Semin Immunopathol. 23 (3): 253–65. PMID 11591101.

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