Microscopic polyangiitis laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]
Overview
Laboratory findings consistent with the diagnosis of Microscopic polyangiitis include, leukocytosis, elevated erythrocyte sedimentation rate, proteinuria, hematuria, red cell casts, elevated blood urea nitrogen, elevated serum creatinine, and anti-neutrophil cytoplasmic antibodies.
Laboratory Findings
Laboratory findings consistent with the diagnosis of Microscopic polyangiitis include, anti-neutrophil cytoplasmic antibody, elevated blood urea nitrogen, elevated serum creatinine, elevated erythrocyte sedimentation rate, proteinuria, hematuria, red cell casts and leukocytosis.
Blood Work-up
- Complete blood count
- Serum creatinine
- Blood urea nitrogen
- leukocytosis
- Anti-neutrophil cytoplasmic antibody test
Urianlysis
- Protienuria
- Hematuria
- Red cell casts
Biopsy
Biopsy of the involved skin, lung, renal, and nerve can be made to help establish a diagnosis of Microscopic polyangiitis.
- Skin biopsy is characterized by the presences of immunoglobulins and complement components.
- Renal biopsy is characterized as crescent formation with focal necrosis.
- Lung biopsy is characterized as alveolar capillaritis.
- Nerve biopsy is characterized by vascular necrosis of small and medium sized vessels.