H.pylori gastric adenocarcinoma pathophysiology

	Helicobacter pylori infection Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yamuna Kondapally, M.B.B.S [2]

Overview

Gastric cancer is the second leading cause of cancer-related deaths worldwide and H.pylori is the strongest known risk factor for gastric cancer.^[1]
H.pylori is considered as Type I carcinogen. Among infected individuals, 1 to 3% develop gastric adenocarcinoma.

↑ Uemura N, Okamoto S, Yamamoto S, Matsumura N, Yamaguchi S, Yamakido M; et al. (2001). "Helicobacter pylori infection and the development of gastric cancer". N Engl J Med. 345 (11): 784–9. doi:10.1056/NEJMoa001999. PMID 11556297.