Sandbox:splenic abscess

Overview

Splenic abscess is an uncommon and lifethreatening condition. Clinical presentation, etiological factors, natural history, treatment and prognosis depends on whether the abscess was solitary or multiple.

Historical Perspective

• Since the times of Hippocrates, splenic abscess has been reported several times and he described the natural history and prognosis of splenic abscess.
• In the early days of 20th century, splenic abscess most commonly caused by typhoid and then followed by malaria.

Classification

• Unilocular abscess
• Bilocular abscess

• Solitary abscess
• Multiple abscesses: More common in HIV patients.

Pathophysiology

Splenic abscess can result from various sources such as

• Splenic trauma or splenic laceration
• Hematogenous spread of bacteria
• Contiguous spread of bacteria

Casuses

Spleenic abscess is caused mostly by monomicrobial but some times it can be caused by polymicrobial agents. Bacteria is more common than other microbial agents such as fungi, protozoa which can cause splenic abscess in immunocompromised patients.

• Primary diseases of spleen
• Hemoglobinopathies

Common causes includes:

• Esherichia coli
• Staphylococcus aureus
• Klebsiella pneumonia

Other causes include:

• Streptococcus pyogenes
• Streptococcus pneumonia
• Klebsiella pneumonia
• Bacteroides fragilis
• Pseudomonas aeruginosa
• Staphylococcus aureus
• Proteus mirabilis
• Bacillus cereus
• Salmonella typhi
• Malaria

Monomicrobial Most common causes

Risk Factors

Common risk factors of splenic abscess include:

• Diabetes mellitus
• Immunocompromised conditions such as AIDS
• Pulmonary tuberculosis
• Concomitant parenchymal liver disease such as cirrhosis
• Malignancies
• Trauma

Differentiating splenic abscess from other diseases

Splenic abscess should be differented from other causes of left upper quadrent pain causes:

• Splenic cysts
• Splenic hematomas

Difference between Solitary abscess and Multiple septic abscesses

Characteristic	Solitary abscess	Multiple septic abscesses
Presentation		Most commonly present with generalized sepsis because of an ineradicable septic focus remote from the spleen Epidemiology and Demographics Incidence Indceidence of spelenic abscess varies between 0.1% to 0.7%. Prevalence Prevalence of splenic abscess is increasing gradually due to increased risk factors and increased imaging modalities that can diagnose more accurately. Case Fatality Rate Splenic abscesses are associate with increased morbidity and mortality. Natural History, Complications and Prognosis Splenic abscess is a rare cause of abdominal abscesss, but life-threatening. Because of it's rarity, splenic abscess usually diagnosed at the late stages or after the onset of complications. Early diagnosis, prompt treatment can prevent complications. Complications Common complicaiton include: Bacterial sepsis or septicemia Respiratory complications such as post operative pneumonia Other complications include: Wound infection Paralytic ileus Deep vein thrombosis Meningitis Association Splenic abscess is commonly associate with: Paranchymal liver disease Pancreatitis Pleural effusion Renal cysts Ovarian cysts Abdominal lymphadenopathy Diagnosis Splenic abscess commonly present with a triad of symptoms include fever, nausea, vomiting and abdominal pain along with palpable spleen on examination. Early diagnosis with imaging studies and prompt drainage is required to reduce morbidity and mortality. History and Symptoms Common symptoms of splenic abscess include: Fever Abdominal pain Nausea and vomiting Physical Examination Findings Abdominal Examination Tender splenomegaly Palpable spleen Laboratory Tests Blood Tests Blood tests such leukocytosis are increased but not significant in the diagnosis of splenic abscess because these tests may not be appropriate in immunocompromised patients. CBC with differential Erythrocyte sedimentation ratio (ESR) Blood culture Imaging As the clinical features of splenic absecess are non specific and vague such as abdominal pain, fever and vomiting, that makes diagnosis is challenging and relied on imaging modalities. Imaging studies such as ultrasound, computerized tomography made the diagnosis early and more accurate that reduces morbidity and mortality. Ultrasound Computerised Tomography Computerised tomography is both diagnostic and therapeutic test of choice for splenic abscess. Advantages Can differentiate unolocular and multilocular abscesses Can identify the contents of abscess Can differentiate splenic abscess from splenic cysts and splenic hematomas More precise and accurate than ultrasonography, in identifying the location of abscess in relation to other internal organs during per-cutaneous drainage. Treatment Antimicrobial Regimen Percutaneous Drainage Percutaneous drainage is the primary mode of tretament for splenic abscess, even though splenectomy is the definitive treatment because of increased risk of infections in splenectomised patient. It is genereally done under the guidance of imaging studies such as ultrasound or computerised tomography. First line of treatment for splenic abscess Safe and effective than surgery in both unilocular and bilocular abscesses, especially in peripherally located abscesses. Preferred in critically ill patient and patients unfit for general anesthesia Advantages Preserves spleen No abdominal spillage of abscess contents Less expensive, high acceptance rate and less operative risk Complications Splenic haemorrhage Injury to other abdominal organs Septicemia Empyema Pneumothorax Fistula formation Deep vein thrombosis Contraindications Multiple or septated abscesses Anatomically inaccessible for drainage Coagulopathies Ascites Open Drainage Splenectomy Splenectomy is the most effective and definitive treatment of choice for splenic abscess. Advantages Definitive treatment for splenic abscess Treatment of choice if more than 2 abscesses are present Patients with failed percutaneous drainage Patient with recurrent abscesses Disadvantages Splenecetomisesd patients are more prone to infections especially catalase positive bacteria such as staphylococcus aureus. Mortality rate varies between 0-20% Longer duration of hospital stay than percutaneous drainage procedure Complications such as Lung infection Wound infection Septicemia Paralytic ileus Deep vein thrombosis References