Tropical sprue pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
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Overview
Pathophysiology
Histology
The histological changes of TS include: Flattening of the villi and small intestinal inflammation which are similar to an autoimmune disorder Coeliac disease (also known as coeliac sprue). A complete flattening of the villi on small bowel biopsy is an uncommon finding in TS unlike Celiac disease.
| Diagnosis | Villous morphology | Findings in Lamina propria | Involved portion of the GI tract |
|---|---|---|---|
| Tropical sprue | Mild to moderate blunting of the villi with an increased number of Intraepithelial lymphocytes. | Increased number of plasma cells and eosinophils. | Ileum > Duodenum > Colon |
| Celiac sprue | Variable, often there is a complete flattening of the villi. Always there is an increased number of Intraepithelial lymphocytes | Plasma cells > Eosinophils > Neutrophils. | Duodenum > Ileum. |