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Overview
Vaccination is the administration of agent-specific, but relatively harmless, antigenic components that in vaccinated individuals can induce protective immunity against the corresponding infectious agent. In practice, the terms vaccination and immunization are often used interchangeably. Vaccination is highly effective to prevent some particular infections. Vaccines are safe with minimal adverse reactions. vaccination can prevents illness, disability and death from vaccine-preventable diseases including cervical cancer, diphtheria, hepatitis B, measles, mumps, pertussis, pneumonia, polio, rotavirus diarrhea, rubella and tetanus. Vaccines help develop immunity by imitating an infection. This type of infection, however, does not cause illness, but it does cause the immune system to produce T-lymphocytes and antibodies. Immunization currently averts an estimated 2 to 3 million deaths every year. An additional 1.5 million deaths could be avoided, however, if global vaccination coverage improves. An estimated 19.4 million infants worldwide are still missing out on basic vaccines. The material administrated as vaccine, can either be live, but weakened forms of pathogens such as bacteria or viruses, killed or inactivated forms of these pathogens, or purified material such as proteins.
Benjamin Jesty is notable as perhaps the first person recorded to have vaccinated with cowpox in order to artificially induce immunity to smallpox in the epidemic of 1774. The term vaccination was first used by Edward Jenner an English physician 22 years later in 1796. Louis Pasteur further adapted in his pioneering work in microbiology. Vaccination (vacca in latin means cow) is so named because the first vaccine was derived from a virus affecting cow, the relatively benign cowpox virus, which provides a degree of immunity to smallpox, a contagious and deadly disease which, the World Health Organization coordinated the global effort to eradicate this disease. The last naturally occurring case of smallpox occurred in Somalia in 1977.
Vaccine preventable diseases
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Classification
| Immunization | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Passive | Active (vaccination) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Human immune globulin (IG) | Hyperimmune globulin | Monoclonal antibodies | Live, attenuated vaccines | Inactivated vaccines | Toxoid vaccines | Subunit vaccines | Conjugate vaccines | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IV immune globulin (IVIG) | Subcutaneous immune globulin (SCIG) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Passive immunization
Passive immunization is a method of disease prevention by transferring pre-made antibodies to a person at risk of acquiring a certain disease. Although, this type of immunity could be acquired naturally , during pregnancy by trans-placental maternal antibodies' transfer to the fetus. Artificial passive immunization is normally given by pre-made immunoglobulins to a person at risk of acquiring a certain disease.
Human immune globulin (IG)
Human immune globulin is obtained from normal persons and is a concentrated solution of antibodies mainly, IgG antibodies. Human immune globulin is given intra-muscular (IM). Up to 48 hours is required for IGs to reach the maximum serum concentration and their half-life is about 3 weeks. The sooner administration the more effective prevention. IGs only provide temporary protection. Diseases with available human immune globulins include:
- Hepatitis A
- Measles
- Immunoglobulin deficiency
- Varicella (in immunocompromised patients when varicella-zoster IG is unavailable)
- Rubella exposure during the 1st trimester of pregnancy
IV immune globulin (IVIG)
IV immune globulin contains larger amounts of human immune globulin and it administers via IV route. Diseases that may be prevented or ameliorated by using IVIGs include:
- Kawasaki disease
- HIV infection in children
- Chronic B-cell lymphocytic leukemia
- Primary immunodeficiencies
- Immune thrombocytopenia
- Prevention of graft-vs-host disease
Subcutaneous immune globulin (SCIG)
Subcutaneous immune globulin (SCIG) is prepared for home based use especially for persons affected by primary immunodeficiency.
Hyperimmune globulin
Hyperimmune globulin is derived of a person's plasma containing large amounts of antibodies. These persons are whom convalescing from natural infections or donors artificially immunized. Hyperimmune globulins are available for cytomegalovirus, varicella-zoster, hepatitis B, infant botulism, rabies, and tetanus.
Monoclonal antibodies
Specific monoclonal antibodies can be used against infections. The only current available is, palivizumab which is active against RSV.
Active immunization
Live attenuated vaccines
Live attenuated vaccines are produced by modifying a disease-producing (wild) virus or bacterium in a laboratory. The resulting vaccine organism retains the ability to replicate and produce immunity, but usually does not cause illness. These vaccines are produced by growing the virus in tissue cultures that will select for less virulent strains, or by mutagenesis or targeted deletions in genes required for virulence. Attenuated vaccines can not be used by immunocompromised individuals. Examples of live attenuated vaccines include measles, mumps, and rubella vaccine (MMR) and varicella (chickenpox) vaccine.
Inactivated vaccines
These vaccines are made by inactivating or killing the pathogen (mostly, viruses). The inactivated polio vaccine is an example of this type of vaccine.
Toxoid vaccines
Toxoid vaccines are effective against bacteria that produces toxins and they are weakened toxins, produced by particular bacteria. The DTaP vaccine contains diphtheria and tetanus toxoids.
Subunit vaccines
Subunit vaccines contain only some parts of bacteria or virus not the entire germ. Because these vaccines contain only the essential antigens and not all the other molecules that make up the germ, side effects are less common. The pertussis component of the DTaP vaccine is an example of a subunit vaccine.
Conjugate vaccines
Conjugate vaccines are effective against bacteria that have polysaccharides in their cell wall components. Polysaccharides may cause less stimulation of immune system and result in defective immune response. Conjugate vaccines are effective for these types of bacteria because they connect (or conjugate) the polysaccharides to antigens that the immune system responds to very well. This linkage helps the immature immune system react to the coating and develop an immune response. An example of this type of vaccine is the Haemophilus influenzae type B (Hib) vaccine.
Adverse reactions
Adverse reactions to vaccines could be divided to 2 major groups.[8]
- Allergic reactions
- Severe reportable reactions
Allergic reactions
- Immediate reactions: Immediate reactions are IgE related reactions that begins within minutes.
- Delayed reactions: Delayed reactions appear several hours or even days after administration and they are mostly non-IgE related reactions.
Immediate reactions
Anaphylaxis, is rare but important among immediate reactions. Health care providers should be aware of it's symptoms and signs and be prepared for prompt treatment.[9][10]
Other common but less serious immediate reactions include:
- Cutaneous symptoms: Flushing, itching, urticaria, and angioedema
- Respiratory symptoms: Nasal discharge, nasal congestion, change in voice quality, sensation of throat closure or choking, stridor, cough, wheeze, and dyspnea
- Cardiovascular symptoms: Faintness, syncope, altered mental status, palpitations, and hypotension
Delayed reactions
Common delayed reactions to vaccines include:
- Fever: Fever is common after vaccination and should not preclude vaccine in the future.
- Local reactions: Local reactions such as, swelling and erythema are common and can be treated with cold compress.
- Serum sickness and serum sickness-like reactions
Vasovagal reactions
Vasovagal reactions such as, faint, hypotension, pallor, diaphoresis, weakness, nausea, vomiting, bradycardia, and if severe, loss of consciousness may be seen after vaccination.
Reaction to vaccine components
Vaccine constitute such as, gelatin, egg proteins, cow's milk, thimerosal, aluminum, and phenoxyethanol that are used as vaccine preservatives, may cause adverse reactions ranging from fever or skin reactions to severe reactions that may need skin test before future administration.
References
- ↑ Estimated Incidence/deaths World Health Organization Immunization, Vaccines and Biologicals Year 2000 data
- ↑ Reported cases/deaths (pdf) CDC "Pink Pages", Year 2002 data
- ↑ Reported cases/deaths NHS Immunisation Information, Year 2000 data (unless noted)
- ↑ See also: Estimated regional measles deaths (with uncertainty bounds) Fact sheet N°286 (2004). The World Health Organization (WHO) and UNICEF. Revised March 2006.
- ↑ (2005 data) Polio is endemic in only four countries; Nigeria, India, Afghanistan and Pakistan
- ↑ (year 2000: due to neonatal tetanus from non-sterile delivery and/or umbilical severing tools)
- ↑ Reported Tuberculosis in the United States The National Center for HIV, STD, and TB Prevention Statistics: 2002
- ↑ Johansson SG, Bieber T, Dahl R, Friedmann PS, Lanier BQ, Lockey RF, Motala C, Ortega Martell JA, Platts-Mills TA, Ring J, Thien F, Van Cauwenberge P, Williams HC (2004). "Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003". J. Allergy Clin. Immunol. 113 (5): 832–6. doi:10.1016/j.jaci.2003.12.591. PMID 15131563.
- ↑ Sampson HA, Muñoz-Furlong A, Campbell RL, Adkinson NF, Bock SA, Branum A, Brown SG, Camargo CA, Cydulka R, Galli SJ, Gidudu J, Gruchalla RS, Harlor AD, Hepner DL, Lewis LM, Lieberman PL, Metcalfe DD, O'Connor R, Muraro A, Rudman A, Schmitt C, Scherrer D, Simons FE, Thomas S, Wood JP, Decker WW (2006). "Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium". J. Allergy Clin. Immunol. 117 (2): 391–7. doi:10.1016/j.jaci.2005.12.1303. PMID 16461139.
- ↑ McNeil MM, Weintraub ES, Duffy J, Sukumaran L, Jacobsen SJ, Klein NP, Hambidge SJ, Lee GM, Jackson LA, Irving SA, King JP, Kharbanda EO, Bednarczyk RA, DeStefano F (2016). "Risk of anaphylaxis after vaccination in children and adults". J. Allergy Clin. Immunol. 137 (3): 868–78. doi:10.1016/j.jaci.2015.07.048. PMC 4783279. PMID 26452420.