Aphthous ulcer differential diagnosis

Aphthous ulcer Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mehrsefat, M.D. [2]

Overview=

Aphthous ulcer must be differentiated from malignant ulcers, Infections, rheumatic and cutaneous disease.

Differential Diagnosis

Aphthous ulcer must be differentiated from:

• Infections
  • Recurrent infection with herpesvirus
  • HIV infection
  • Intraoral infections
  • Oral candidiasis
  • Hand-foot-and-mouth disease
  • Epstein-Barr virus (EBV) infection (infectious mononucleosis)

• Neoplasms
  • Kaposi’s sarcoma
  • Lymphoma
  • Leukemias

• Rheumatic diseases
  • Behçet’s syndrome
  • Reactive arthritis (Reiter’s syndrome)
  • Sweet’s syndrome
  • MAGIC syndrome (mouth and genital ulcers with inflamed cartilage)

• Cutaneous diseases
  • Erythema multiforme
  • Pemphigus

• Hematologic diseases
  • Cyclic neutropenia

• Nutritional deficiency
  • Iron deficiency
  • Folate deficiency
  • Vitamin B12 deficiency

• Gastro-Intestinal diseases
  • Gluten-sensitive enteropathy
  • Inflammatory bowel disease (ulcerative colitis, Crohn’s disease)

• Drugs
  • Nonsteroidal antiinflammatory drugs
  • Beta-blockers
  • Nicorandil (Ikorel)
  • Alendronate (Fosamax)

References

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