Pheochromocytoma history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]
Overview
Symptoms of pheochromocytoma include episodes of tachycardia, sweating and headaches.[1] Most patients don't have all symptoms.Less common symptoms include cardiomyopathy and episodic hypotension.[2]
History and Symptoms
The hallmark symptoms of a pheochromocytoma are those of sympathetic nervous system hyperactivity, symptoms usually subside in less than one hour and they may include:
- Palpitations especially in epinephrine producing tumors.[3]
- Anxiety often resembling that of a panic attack
- Sweating
- Headaches: occurs in 90 % of patients.
- paroxysmal attacks of hypertension but some patients have normal blood pressure.
- May be asymptomatic and discovered by incidence screening especially MEN patients.
Please note that not all patients with pheochromocytoma experience all classical symptoms.[4]
Less common symptoms include:
- Cardiomyopathy: rare symptom due to catecholamine excess mimics takotsubo cardiomyopathy.[5] Patient improves after medical teatment or surgical removal of tumor.
- Epinephrine secreting masses can cause episodic hypotension.[6]
References
- ↑ Stein PP, Black HR (1991). "A simplified diagnostic approach to pheochromocytoma. A review of the literature and report of one institution's experience". Medicine (Baltimore). 70 (1): 46–66. PMID 1988766.
- ↑ Baguet JP, Hammer L, Mazzuco TL, Chabre O, Mallion JM, Sturm N; et al. (2004). "Circumstances of discovery of phaeochromocytoma: a retrospective study of 41 consecutive patients". Eur J Endocrinol. 150 (5): 681–6. PMID 15132724.
- ↑ Bravo EL, Gifford RW (1993). "Pheochromocytoma". Endocrinol Metab Clin North Am. 22 (2): 329–41. PMID 8325290.
- ↑ Baguet JP, Hammer L, Mazzuco TL, Chabre O, Mallion JM, Sturm N; et al. (2004). "Circumstances of discovery of phaeochromocytoma: a retrospective study of 41 consecutive patients". Eur J Endocrinol. 150 (5): 681–6. PMID 15132724.
- ↑ Kassim TA, Clarke DD, Mai VQ, Clyde PW, Mohamed Shakir KM (2008). "Catecholamine-induced cardiomyopathy". Endocr Pract. 14 (9): 1137–49. doi:10.4158/EP.14.9.1137. PMID 19158054.
- ↑ Bravo EL (1994). "Evolving concepts in the pathophysiology, diagnosis, and treatment of pheochromocytoma". Endocr Rev. 15 (3): 356–68. doi:10.1210/edrv-15-3-356. PMID 8076587.