Primary hyperaldosteronism differential diagnosis

Differentiating Conn's Syndrome From Other Diseases

Conn's syndrome should be differentiated from other diseases causing hypertension and hypokalemia for example:

• Renal artery stenosis
• Cushing's syndrome
• Congenital adrenal hyperplasia (CAH)
  • 17 alpha hydroxylase deficiency
  • 11 beta hydroxylase deficiency
• Liddle's syndrome
• Diuretic use
• Licorice ingestion
• Renin-secreting tumors

{{familytree | | | |I01| | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |I02|I01=• Deoxycorticosterone excess( 17 alpha hydroxylase and 11 beta hydroxylase deficiency
• Licorice ingestion
•Glucocorticoid resistance|I02=Liddle's syndrome) Template:WH Template:WS

Hypertension and Hypokalemia

Plasma renin activity

Normal or High (Plasma Renin/Aldosterone ratio <10

Suppressed (Plasma Renin/Aldosterone ratio >20

*Renin-secreting tumors *Diuretic use *Renovascular hypertension *Coarctation of aorta *Malignant phase hypertension

Urinary aldosterone

Elevated

Normal

Low

Conn's syndrome (Primary aldosteronism)

Profound K+ depletion

• 17 alpha hydroxylase deficiency • 11 beta hydroxylase deficiency • Liddle's syndrome • Licorice ingestion • Deoxycortisone producing tumor

Add Mineralocrticoid antagonist for 8 weeks

BP response

No BP response

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