Cushing's syndrome natural history, complications and prognosis
|
Cushing's syndrome Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Cushing's syndrome natural history, complications and prognosis On the Web |
|
American Roentgen Ray Society Images of Cushing's syndrome natural history, complications and prognosis |
|
FDA on Cushing's syndrome natural history, complications and prognosis |
|
CDC on Cushing's syndrome natural history, complications and prognosis |
|
Cushing's syndrome natural history, complications and prognosis in the news |
|
Blogs on Cushing's syndrome natural history, complications and prognosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]
Overview
Natural History
Complications
- Insulin resistance (especially common in ectopic ACTH production), leading to hyperglycemia (high blood sugars) which can lead to diabetes mellitus.
- Untreated Cushing's syndrome can lead to myocardial infarction, left ventricular dysfunction, and cerebrovascular disease.
Cushing’s syndrome creates a hypercoagulable state due to an activated coagulation cascade and impaired fibrinolysis with non-malignant Cushing’s syndrome have a more than ten-fold increased risk of developing venous thromboembolic disease.16Major depression and anxiety disorders are common, but acute psychosis is rare.162,163 Cognitive deficits include memory dysfunction, poor visual memory, impaired decision making, and sleep disturbances.162–165 The immunosuppressive eff ects of Cushing’s syndrome increase susceptibility to opportunistic infections and sepsis.
Prognosis
The prognosis for those with Cushing's syndrome varies depending on the cause of the disease. Most cases of Cushing's syndrome can be cured. Many individuals with Cushing's syndrome show significant improvement with treatment, although some may find recovery complicated by various aspects of the causative illness. Some kinds of tumors may recur. Mortality in the patients with Cushing's syndrome is increased even after the apparently successful treatment.[1]
References
- ↑ Lodish M (2015). "Cushing's syndrome in childhood: update on genetics, treatment, and outcomes". Curr Opin Endocrinol Diabetes Obes. 22 (1): 48–54. doi:10.1097/MED.0000000000000127. PMC 4415092. PMID 25517021.