Zollinger-Ellison syndrome causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2] Mohamad Alkateb, MBBCh [3]
Overview
The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of gastrinomas, which can cause Zollinger-Ellison syndrome, are caused by multiple endocrine neoplasia type 1 (MEN1).
Causes
- The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of gastrinomas, which can cause Zollinger-Ellison syndrome, are caused by multiple endocrine neoplasia type 1 (MEN1).[1]
- Causes of Hypergastrinemia: [2]
| Causes of Hypergastrinemia | ||
| Appropriate hypergastrinemia | ||
| Atrophic gastritis with or without pernicious anemia | ||
| Antisecretory therapy (PPIs or high-dose histamine H2-receptor antagonist) | ||
| Chronic renal failure | ||
| H pylori pangastritis | ||
| Vagotomy | ||
| Inappropriate hypergastrinemia | ||
| ZES (sporadic or associated with MEN-1) | ||
| Antral-predominant H pylori infection | ||
| Retained-antrum syndrome | ||
| Gastric-outlet obstruction | ||
| Small-bowel resection | ||
| Spurious hypergastrinemia | ||
| Nonfasting patient | ||
| Inaccurate assay | ||
References
- ↑ National Institute of Diabetes and Digestive and Kidney Diseases.http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/zollinger-ellison-syndrome/Pages/facts.aspx#causes
- ↑ Metz DC (2012). "Diagnosis of the Zollinger–Ellison syndrome". Clin Gastroenterol Hepatol. 10 (2): 126–30. doi:10.1016/j.cgh.2011.07.012. PMID 21806955.