Diabetic ketoacidosis causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Sugar which is the main source of energy for cells, need insulin to enter inside the cells. When the patient lack enough Insulin, sugar will not be able to enter inside the cell. This situation prompts the release of certain hormones that break down fat. The breakdown of fat produces ketones bodies. This process is triggered in the presence of any infection or illness.

Causes

The following are the causes of diabetic ketoacidosis (DKA):

Common Causes

• Drugs:
  • Antipsychotic agents: clozapine, olanzapine, risperidone
  • Illicit drugs (cocaine and alcohol)
  • Others: corticosteroids, glucagon, interferon, pentamidine, sympathomimetic agents, thiazide diuretics

• Infections:
  • Pneumonia
  • Sepsis
  • Urinary tract infection

• Lack of insulin
• Nonadherence to insulin treatment plans:
  • Body image issues
  • Financial problems
  • Psychological factors

• Unrecognized symptoms of new-onset diabetes mellitus

• Physiological stressors:
  • Acromegaly
  • Thrombosis
  • Cerebrovascular accident
  • Cushing disease
  • Hemochromatosis
  • Myocardial infarction
  • Pancreatitis
  • Pregnancy
  • Psychological stress
  • Shock/hypovolemia
  • Trauma