Euthyroid sick syndrome causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Causes
- Euthyroid sick syndrome can be caused by any serious illness which predisposes to:
- Increased level of cytokines
- Decreased level of leptin
- Hyper-metabolism
- Iodine containing contrast medium
- Decreased protein synthesis
- Decreased level of thyroid-binding globulin
- The following table summarize the effect of various drugs on thyroid hormones level.
| ↓ Hormone secretion | ↓ T4 | ↓ TSH | ↓ 5' monodeiodinase | ↑ Breakdown | ↑ TBG | ↓TBG |
|---|---|---|---|---|---|---|
| Lithium
Amiodarone |
Aluminum hydroxide
Ferrous sulphate Sucralfate |
Dopamine
Octreotide Glucocorticoids |
Propylthiouracil
Amiodarone Propranolol (high dose) |
Phenobarbital
Rifampin Phenytoin Carbamazepine |
Estrogens
Tamoxifen Fluorouracil Methadone Heroin |
Androgens
Anabolic steroids Glucocorticoids Furosemide Mefenamic acid Salicylates |
- {| class="wikitable" !↓ Hormone secretion !↓ T4 |↓ TSH |↓ 5'monodeiodinase |↑ Breakdown |↑ TBG |↓TBG |- |Lithium Amiodarone |Aluminum hydroxide Ferrous sulphate Sucralfate |Dopamine Octreotide Glucocorticoids |Propylthiouracil Amiodarone Propranolol (high dose) |Phenobarbital Rifampin, Phenytoin, Carbamazepine |Estrogens Tamoxifen Fluorouracil Methadone Heroin |Androgens Anabolic steroids Glucocorticoids Furosemide Mefenamic acid Salicylates |}
- Disease name] may be caused by [cause1], [cause2], or [cause3].
- Common causes of [disease] include [cause1], [cause2], and [cause3].
- The most common cause of [disease name] is [cause 1]. Less common causes of [disease name] include [cause 2], [cause 3], and [cause 4].
- The cause of [disease name] has not been identified. To review risk factors for the development of [disease name], click here.
Causes
Life-threatening Causes
- Life-threatening causes of [symptom/manifestation] include [cause1], [cause2], and [cause3].
- [Cause] is a life-threatening cause of [disease].
Common Causes
[Disease name] may be caused by:
- [cause1]
- [cause2]
- [cause3]
- [Disease name] is caused by an infection with [pathogen name].
- [Pathogen name] is caused by [pathogen name].
Less Common Causes
Less common causes of disease name include:
- [cause1]
- [cause2]
- [cause3]
Genetic Causes
- [Disease name] is caused by a mutation in the [gene name] gene.
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | No underlying causes |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | No underlying causes |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | No underlying causes |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | No underlying causes |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
Causes in Alphabetical Order
List the causes of the disease in alphabetical order.
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